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Louis J. Ignarro (d. 31 Mayıs 1941) Amerikalı farmakolog. Nitrik oksitin etkileşimlerini gösteren çalışmasıyla Robert F. Furchgott ve Ferid Murad ile birlikte 1998 Nobel Fizyoloji veya Tıp Ödülü'nü almıştır. 1985 yılından beri 'nde farmakoloji profesörü olarak çalışmaktadır. Araştırmaları konusunda birçok makale yayınlamış olan Ignarro, kardiyovasküler bilimin ilerlemesine yaptığı katkılar nedeniyle 1998'de 'nin Temel Araştırma Ödülü'nü de almıştır. Aynı yıl ABD Ulusal Bilimler Akademisi'ne, bir sonraki yıl ise Amerikan Sanat ve Bilimler Akademisi'ne kabul edilmiştir.
Louis J. Ignarro | |
|---|---|
 Louis J. Ignarro | |
| Doğum | 31 Mayıs 1941 Brooklyn, New York, ABD |
| Vatandaşlık | ABD |
| Mezun olduğu okul(lar) | Columbia University University of Minnesota |
| Ödüller | Nobel Fizyoloji veya Tıp Ödülü (1998) |
| Kariyeri | |
| Dalı | Farmakoloji |
| Çalıştığı kurumlar | |
Yayınlanmış kitapları
- NO More Heart Disease: How Nitric Oxide Can Prevent – Even Reverse – Heart Disease and Strokes. New York: St. Martin's Press (2005). .
- Nitric Oxide: Biology and Pathobiology. Academic Press (2009). .
- Health Is Wealth: 10 Power Nutrients That Increase Your Odds Of Living To 100. Health Value Publications (2009). .
- Health Is Wealth: Performance Nutrition. Health Value Publications (2011). .
- Survival of the Firmest: UCLA Doctors Describe Ten Steps to Better Erections, a Longer Life and Reversing Erectile Dysfunction (ED). CreateSpace (2011). .
Önemli yayınları
- 1979 CA Gruetter, BK Barry, DB McNamara, DY Gruetter, PJ Kadowitz and LJ Ignarro. Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. J. Cyclic Nucl. Res. 5: 211–224.
- 1980 LJ Ignarro and CA Gruetter. Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: Possible involvement of S-nitrosothiols. Biochim. Biophys. Acta 631: 221–231.
- 1981 BT Mellion, LJ Ignarro, EH Ohlstein, EG Pontecorvo, AL Hyman and PJ Kadowitz. Evidence for the inhibitory role of guanosine 3’,5’-monophosphate in ADP-induced human platelet aggregation. Blood 57: 946–955.
- 1981 LJ Ignarro, H Lippton, JC Edwards, WH Baricos, AL Hyman, PJ Kadowitz and CA Gruetter. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of Snitrosothiols as active intermediates. J. Pharmacol. Exp. Ther. 218: 739–749.
- 1982 MS Wolin, KS Wood and LJ Ignarro. Guanylate cyclase from bovine lung: a kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme and nitrosyl-heme. J. Biol. Chem. 257: 13312-13320.
- 1984 LJ Ignarro, B Ballot and KS Wood. Regulation of guanylate cyclase activity by porphyrins and metalloporphyrins. J. Biol. Chem. 259: 6201–6207.
- 1986 LJ Ignarro, RG Harbison, KS Wood and PJ Kadowitz. Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J. Pharmacol. Exp. Ther. 237: 893–900.
- 1987 LJ Ignarro, RE Byrns, GM Buga and KS Wood. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacological and chemical properties that are identical to those for nitric oxide radical. Circ. Res. 61: 866–879.
- 1987 LJ Ignarro, GM Buga, KS Wood, RE Byrns and G Chaudhuri. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA 84: 9265–9269.
- 1990 LJ Ignarro, PA Bush, GM Buga, KS Wood, JM Fukuto and J Rajfer. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem. Biophys. Res. Commun. 170: 843–850.
- 1992 J Rajfer, WJ Aronson, PA Bush, FJ Dorey and LJ Ignarro. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N. Engl. J. Med. 326: 90–94.
- 1994 JM Griscavage, JM Fukuto, Y Komori and LJ Ignarro. Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group: role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide. J. Biol. Chem. 269: 21644-21649.
- 1994 AJ Hobbs, JM Fukuto and LJ Ignarro. Formation of free nitric oxide from Larginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase. Proc. Natl. Acad. Sci. USA 91: 10992-10996.
- 1996 JM Griscavage, S Wilk and LJ Ignarro. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of nuclear factor-kappa B. Proc. Natl. Acad. Sci. USA 93:3308–3312.
- 1999 HC Champion, TJ Bivalacqua, AL Hyman, LJ Ignarro, WJG Hellstrom and PJ Kadowitz. Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Proc. Natl. Acad. Sci. USA 96:11648-11652.
- 2001 LJ Ignarro, GM Buga, LH Wei, PM Bauer, G Wu and P del Soldato. Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc. Natl. Acad. Sci. USA 98: 4202–4208.
- 2001 PM Bauer, GM Buga, JM Fukuto, AE Pegg and LJ Ignarro. Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. J. Biol. Chem. 276: 34458-34464.
- 2001 PM Bauer, GM Buga and LJ Ignarro. Role of p42/p44 mitogen-activated protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide. Proc. Natl. Acad. Sci. USA 98: 12802-12807.
- 2003 F de Nigris, LO Lerman, SW Ignarro, G Sica, A Lerman, W Palinski, LJ Ignarro and C Napoli. Beneficial effects of antioxidants and L-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress. Proc. Natl. Acad. Sci. USA 100:1420–1425.
- 2003 D Sumi and LJ Ignarro. Estrogen-related receptor alpha 1 up-regulates endothelial nitric oxide synthase expression. Proc. Natl. Acad. Sci. USA 100:14451-14456.
- 2004 T Hayashi, D Sumi, PA Juliet, H Matsui-Hirai, Y Asai-Tanaka, H Kano, A Fukatsu, T Tsunekawa, A Miyazaki, A Iguchi and LJ Ignarro. Gene transfer of endothelial NO synthase, but not eNOS plus inducible NOS, regressed atherosclerosis in rabbits. Cardiovasc. Res. 61:339–351.
- 2004 C Napoli, SW Ignarro, F de Nigris, LO Lerman, L Rossi, C Guarino, G Mansueto, F Di Tuoro, O Pignalosa, G De Rosa, V Sica and LJ Ignarro. Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice. Proc. Natl. Acad. Sci. USA 101:8797–8802.
- 2005 HJ Garban, D Marquez-Garban, R Pietras and LJ Ignarro. Rapid nitric oxidemediated S-nitrosylation of estrogen receptor: Regulation of estrogen-dependent gene transcription. Proc. Natl. Acad. Sci. USA 102:2632–2636.
Dış bağlantılar
- Louis Ignarro's Official Homepage14 Mart 2015 tarihinde Wayback Machine sitesinde .
- Nobel Prize Autobiography23 Aralık 2011 tarihinde Wayback Machine sitesinde .
- , Herbalife.com
- UCLA A Conversation with UCLA Professor Louis J. Ignarro Winner of the 1998 Nobel Prize in Medicine
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Louis J Ignarro d 31 Mayis 1941 Amerikali farmakolog Nitrik oksitin etkilesimlerini gosteren calismasiyla Robert F Furchgott ve Ferid Murad ile birlikte 1998 Nobel Fizyoloji veya Tip Odulu nu almistir 1985 yilindan beri nde farmakoloji profesoru olarak calismaktadir Arastirmalari konusunda bircok makale yayinlamis olan Ignarro kardiyovaskuler bilimin ilerlemesine yaptigi katkilar nedeniyle 1998 de nin Temel Arastirma Odulu nu de almistir Ayni yil ABD Ulusal Bilimler Akademisi ne bir sonraki yil ise Amerikan Sanat ve Bilimler Akademisi ne kabul edilmistir Louis J IgnarroLouis J IgnarroDogum31 Mayis 1941 83 yasinda Brooklyn New York ABDVatandaslikABDMezun oldugu okul lar Columbia University University of MinnesotaOdullerNobel Fizyoloji veya Tip Odulu 1998 KariyeriDaliFarmakolojiCalistigi kurumlarYayinlanmis kitaplariNO More Heart Disease How Nitric Oxide Can Prevent Even Reverse Heart Disease and Strokes New York St Martin s Press 2005 ISBN 0312335822 Nitric Oxide Biology and Pathobiology Academic Press 2009 ISBN 0123738660 Health Is Wealth 10 Power Nutrients That Increase Your Odds Of Living To 100 Health Value Publications 2009 ISBN 0979022916 Health Is Wealth Performance Nutrition Health Value Publications 2011 ISBN 978 1 61389 002 8 Survival of the Firmest UCLA Doctors Describe Ten Steps to Better Erections a Longer Life and Reversing Erectile Dysfunction ED CreateSpace 2011 ISBN 1461150833 Onemli yayinlari1979 CA Gruetter BK Barry DB McNamara DY Gruetter PJ Kadowitz and LJ Ignarro Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide nitroprusside and a carcinogenic nitrosoamine J Cyclic Nucl Res 5 211 224 1980 LJ Ignarro and CA Gruetter Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite Possible involvement of S nitrosothiols Biochim Biophys Acta 631 221 231 1981 BT Mellion LJ Ignarro EH Ohlstein EG Pontecorvo AL Hyman and PJ Kadowitz Evidence for the inhibitory role of guanosine 3 5 monophosphate in ADP induced human platelet aggregation Blood 57 946 955 1981 LJ Ignarro H Lippton JC Edwards WH Baricos AL Hyman PJ Kadowitz and CA Gruetter Mechanism of vascular smooth muscle relaxation by organic nitrates nitrites nitroprusside and nitric oxide Evidence for the involvement of Snitrosothiols as active intermediates J Pharmacol Exp Ther 218 739 749 1982 MS Wolin KS Wood and LJ Ignarro Guanylate cyclase from bovine lung a kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX heme and nitrosyl heme J Biol Chem 257 13312 13320 1984 LJ Ignarro B Ballot and KS Wood Regulation of guanylate cyclase activity by porphyrins and metalloporphyrins J Biol Chem 259 6201 6207 1986 LJ Ignarro RG Harbison KS Wood and PJ Kadowitz Activation of purified soluble guanylate cyclase by endothelium derived relaxing factor from intrapulmonary artery and vein stimulation by acetylcholine bradykinin and arachidonic acid J Pharmacol Exp Ther 237 893 900 1987 LJ Ignarro RE Byrns GM Buga and KS Wood Endothelium derived relaxing factor from pulmonary artery and vein possesses pharmacological and chemical properties that are identical to those for nitric oxide radical Circ Res 61 866 879 1987 LJ Ignarro GM Buga KS Wood RE Byrns and G Chaudhuri Endothelium derived relaxing factor produced and released from artery and vein is nitric oxide Proc Natl Acad Sci USA 84 9265 9269 1990 LJ Ignarro PA Bush GM Buga KS Wood JM Fukuto and J Rajfer Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle Biochem Biophys Res Commun 170 843 850 1992 J Rajfer WJ Aronson PA Bush FJ Dorey and LJ Ignarro Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic noncholinergic neurotransmission N Engl J Med 326 90 94 1994 JM Griscavage JM Fukuto Y Komori and LJ Ignarro Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide J Biol Chem 269 21644 21649 1994 AJ Hobbs JM Fukuto and LJ Ignarro Formation of free nitric oxide from Larginine by nitric oxide synthase direct enhancement of generation by superoxide dismutase Proc Natl Acad Sci USA 91 10992 10996 1996 JM Griscavage S Wilk and LJ Ignarro Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of nuclear factor kappa B Proc Natl Acad Sci USA 93 3308 3312 1999 HC Champion TJ Bivalacqua AL Hyman LJ Ignarro WJG Hellstrom and PJ Kadowitz Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat Proc Natl Acad Sci USA 96 11648 11652 2001 LJ Ignarro GM Buga LH Wei PM Bauer G Wu and P del Soldato Role of the arginine nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation Proc Natl Acad Sci USA 98 4202 4208 2001 PM Bauer GM Buga JM Fukuto AE Pegg and LJ Ignarro Nitric oxide inhibits ornithine decarboxylase via S nitrosylation of cysteine 360 in the active site of the enzyme J Biol Chem 276 34458 34464 2001 PM Bauer GM Buga and LJ Ignarro Role of p42 p44 mitogen activated protein kinase and p21waf1 cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide Proc Natl Acad Sci USA 98 12802 12807 2003 F de Nigris LO Lerman SW Ignarro G Sica A Lerman W Palinski LJ Ignarro and C Napoli Beneficial effects of antioxidants and L arginine on oxidation sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress Proc Natl Acad Sci USA 100 1420 1425 2003 D Sumi and LJ Ignarro Estrogen related receptor alpha 1 up regulates endothelial nitric oxide synthase expression Proc Natl Acad Sci USA 100 14451 14456 2004 T Hayashi D Sumi PA Juliet H Matsui Hirai Y Asai Tanaka H Kano A Fukatsu T Tsunekawa A Miyazaki A Iguchi and LJ Ignarro Gene transfer of endothelial NO synthase but not eNOS plus inducible NOS regressed atherosclerosis in rabbits Cardiovasc Res 61 339 351 2004 C Napoli SW Ignarro F de Nigris LO Lerman L Rossi C Guarino G Mansueto F Di Tuoro O Pignalosa G De Rosa V Sica and LJ Ignarro Long term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice Proc Natl Acad Sci USA 101 8797 8802 2005 HJ Garban D Marquez Garban R Pietras and LJ Ignarro Rapid nitric oxidemediated S nitrosylation of estrogen receptor Regulation of estrogen dependent gene transcription Proc Natl Acad Sci USA 102 2632 2636 Dis baglantilarLouis Ignarro s Official Homepage14 Mart 2015 tarihinde Wayback Machine sitesinde Nobel Prize Autobiography23 Aralik 2011 tarihinde Wayback Machine sitesinde Herbalife com UCLA A Conversation with UCLA Professor Louis J Ignarro Winner of the 1998 Nobel Prize in Medicine