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NADPH oksidaz 1, insanlarda NOX1 geni tarafından kodlanan bir enzimdir.
NOX1, fagositlerin süperoksit üreten NADPH oksidazının katalitik alt biriminin, gp91phox, bir homologudur. Bu gen için farklı izoformları kodlayan iki transkript varyantı bulunmuştur.
Kaynakça
Konuyla ilgili yayınlar
- Lachgar A, Sojic N, Arbault S, ve diğerleri. (1999). "Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1-immunosuppressive tat and gp160 proteins". J. Virol. 73 (2): 1447-52. (PMC) 103969 $2. (PMID) 9882350.
- Kikuchi H, Hikage M, Miyashita H, Fukumoto M (2000). "NADPH oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon epithelial cells". Gene. 254 (1–2): 237-43. (PMID) 10974555.
- Dahlgren C, Karlsson A (2002). "Ionomycin-induced neutrophil NADPH oxidase activity is selectively inhibited by the serine protease inhibitor diisopropyl fluorophosphate". Antioxid. Redox Signal. 4 (1): 17-25. (PMID) 11970839.
- (2002). "The activity of leukocyte NADPH oxidase: regulation by p47PHOX cysteine and serine residues". Antioxid. Redox Signal. 4 (1): 35-8. (PMID) 11970841.
- Strausberg RL, Feingold EA, Grouse LH, ve diğerleri. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. (PMC) 139241 $2. (PMID) 12477932.
- Geiszt M, Lekstrom K, Witta J, Leto TL (2003). "Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells". J. Biol. Chem. 278 (22): 20006-12. (PMID) 12657628.
- Takeya R, Ueno N, Kami K, ve diğerleri. (2003). "Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases". J. Biol. Chem. 278 (27): 25234-46. (PMID) 12716910.
- Geiszt M, Lekstrom K, Brenner S, ve diğerleri. (2003). "NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes". J. Immunol. 171 (1): 299-306. (PMID) 12817011.
- Chamulitrat W, Schmidt R, Tomakidi P, ve diğerleri. (2003). "Association of gp91phox homolog Nox1 with anchorage-independent growth and MAP kinase-activation of transformed human keratinocytes". Oncogene. 22 (38): 6045-53. (PMID) 12955083.
- Cheng G, Lambeth JD (2004). "NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain". J. Biol. Chem. 279 (6): 4737-42. (PMID) 14617635.
- Hilenski LL, Clempus RE, Quinn MT, ve diğerleri. (2004). "Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells". Arterioscler. Thromb. Vasc. Biol. 24 (4): 677-83. (PMID) 14670934.
- Morré DM, Guo F, Morré DJ (2004). "An aging-related cell surface NADH oxidase (arNOX) generates superoxide and is inhibited by coenzyme Q". Mol. Cell. Biochem. 254 (1–2): 101-9. (PMID) 14674687.
- Chamulitrat W, Stremmel W, Kawahara T, ve diğerleri. (2004). "A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes". J. Invest. Dermatol. 122 (4): 1000-9. (PMID) 15102091.
- Goyal P, Weissmann N, Grimminger F, ve diğerleri. (2004). "Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species". Free Radic. Biol. Med. 36 (10): 1279-88. (PMID) 15110393.
- Barbieri SS, Cavalca V, Eligini S, ve diğerleri. (2005). "Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms". Free Radic. Biol. Med. 37 (2): 156-65. (PMID) 15203187.
- Guzik TJ, Sadowski J, Kapelak B, ve diğerleri. (2005). "Systemic regulation of vascular NAD(P)H oxidase activity and nox isoform expression in human arteries and veins". Arterioscler. Thromb. Vasc. Biol. 24 (9): 1614-20. (PMID) 15256399.
- Ambasta RK, Kumar P, Griendling KK, ve diğerleri. (2004). "Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase". J. Biol. Chem. 279 (44): 45935-41. (PMID) 15322091.
- Geiszt M, Lekstrom K, Leto TL (2005). "Analysis of mRNA transcripts from the NAD(P)H oxidase 1 (Nox1) gene. Evidence against production of the NADPH oxidase homolog-1 short (NOH-1S) transcript variant". J. Biol. Chem. 279 (49): 51661-8. (PMID) 15375166.
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NADPH oksidaz 1 insanlarda NOX1 geni tarafindan kodlanan bir enzimdir NOX1 fagositlerin superoksit ureten NADPH oksidazinin katalitik alt biriminin gp91phox bir homologudur Bu gen icin farkli izoformlari kodlayan iki transkript varyanti bulunmustur Kaynakca Cell transformation by the superoxide generating oxidase Mox1 Nature 401 6748 79 82 Sep 1999 doi 10 1038 43459 PMID 10485709 Entrez Gene NOX1 NADPH oxidase 1 2 Kasim 2008 tarihinde kaynagindan Konuyla ilgili yayinlarLachgar A Sojic N Arbault S ve digerleri 1999 Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1 immunosuppressive tat and gp160 proteins J Virol 73 2 1447 52 PMC 103969 2 PMID 9882350 Kikuchi H Hikage M Miyashita H Fukumoto M 2000 NADPH oxidase subunit gp91 phox homologue preferentially expressed in human colon epithelial cells Gene 254 1 2 237 43 PMID 10974555 Dahlgren C Karlsson A 2002 Ionomycin induced neutrophil NADPH oxidase activity is selectively inhibited by the serine protease inhibitor diisopropyl fluorophosphate Antioxid Redox Signal 4 1 17 25 PMID 11970839 2002 The activity of leukocyte NADPH oxidase regulation by p47PHOX cysteine and serine residues Antioxid Redox Signal 4 1 35 8 PMID 11970841 Strausberg RL Feingold EA Grouse LH ve digerleri 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 PMC 139241 2 PMID 12477932 Geiszt M Lekstrom K Witta J Leto TL 2003 Proteins homologous to p47phox and p67phox support superoxide production by NAD P H oxidase 1 in colon epithelial cells J Biol Chem 278 22 20006 12 PMID 12657628 Takeya R Ueno N Kami K ve digerleri 2003 Novel human homologues of p47phox and p67phox participate in activation of superoxide producing NADPH oxidases J Biol Chem 278 27 25234 46 PMID 12716910 Geiszt M Lekstrom K Brenner S ve digerleri 2003 NAD P H oxidase 1 a product of differentiated colon epithelial cells can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes J Immunol 171 1 299 306 PMID 12817011 Chamulitrat W Schmidt R Tomakidi P ve digerleri 2003 Association of gp91phox homolog Nox1 with anchorage independent growth and MAP kinase activation of transformed human keratinocytes Oncogene 22 38 6045 53 PMID 12955083 Cheng G Lambeth JD 2004 NOXO1 regulation of lipid binding localization and activation of Nox1 by the Phox homology PX domain J Biol Chem 279 6 4737 42 PMID 14617635 Hilenski LL Clempus RE Quinn MT ve digerleri 2004 Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells Arterioscler Thromb Vasc Biol 24 4 677 83 PMID 14670934 Morre DM Guo F Morre DJ 2004 An aging related cell surface NADH oxidase arNOX generates superoxide and is inhibited by coenzyme Q Mol Cell Biochem 254 1 2 101 9 PMID 14674687 Chamulitrat W Stremmel W Kawahara T ve digerleri 2004 A constitutive NADPH oxidase like system containing gp91phox homologs in human keratinocytes J Invest Dermatol 122 4 1000 9 PMID 15102091 Goyal P Weissmann N Grimminger F ve digerleri 2004 Upregulation of NAD P H oxidase 1 in hypoxia activates hypoxia inducible factor 1 via increase in reactive oxygen species Free Radic Biol Med 36 10 1279 88 PMID 15110393 Barbieri SS Cavalca V Eligini S ve digerleri 2005 Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox dependent mechanisms Free Radic Biol Med 37 2 156 65 PMID 15203187 Guzik TJ Sadowski J Kapelak B ve digerleri 2005 Systemic regulation of vascular NAD P H oxidase activity and nox isoform expression in human arteries and veins Arterioscler Thromb Vasc Biol 24 9 1614 20 PMID 15256399 Ambasta RK Kumar P Griendling KK ve digerleri 2004 Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase J Biol Chem 279 44 45935 41 PMID 15322091 Geiszt M Lekstrom K Leto TL 2005 Analysis of mRNA transcripts from the NAD P H oxidase 1 Nox1 gene Evidence against production of the NADPH oxidase homolog 1 short NOH 1S transcript variant J Biol Chem 279 49 51661 8 PMID 15375166