NADPH oxidaz 4, insanlarda NOX4 ile kodlanan ve NADPH oksidazların NOX ailesine üye enzim.
Fonksiyon
Oksijen algılama, tüm aerobik organizmalarda homeostaz için gereklidir. Nötrofil granülositlerdeki büyük miktarlarda reaktif oksijen türlerinin (ROS) üretiminden sorumlu olana benzer bir fagosit tipi oksidazın böbrekte, böbrek korteksindeki eritropoietin sentezini düzenleyen bir oksijen sensörü olarak işlev gördüğü ileri sürülmüştür.
Nox4, damar sistemini inflamatuvar strese karşı korur. Amino endoperoksitler tarafından Nox bağımlı reaktif oksijen türü modülasyonu, yüksek Nox4 eksprese eden kanser hücrelerinde apoptozu indükleyebilir.
Kaynakça
- ^ a b "Entrez Gene: NOX4 NADPH oxidase 4". 2 Kasım 2008 tarihinde kaynağından .
- ^ "Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase". Circ. Res. 110 (9): 1217-25. Nisan 2012. doi:10.1161/CIRCRESAHA.112.267054. (PMID) 22456182.
- ^ "Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells". Cell Death Dis. 4 (3): e552. Mart 2013. doi:10.1038/cddis.2013.68. (PMC) 3615744 $2. (PMID) 23519121.
Konuyla ilgili yayınlar
- Lachgar A, Sojic N, Arbault S, ve diğerleri. (1999). "Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1-immunosuppressive tat and gp160 proteins". J. Virol. 73 (2): 1447-52. doi:10.1128/JVI.73.2.1447-1452.1999. (PMC) 103969 $2. (PMID) 9882350.
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- Chamulitrat W, Stremmel W, Kawahara T, ve diğerleri. (2004). "A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes". J. Invest. Dermatol. 122 (4): 1000-9. doi:10.1111/j.0022-202X.2004.22410.x. (PMID) 15102091.
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NADPH oxidaz 4 insanlarda NOX4 ile kodlanan ve NADPH oksidazlarin NOX ailesine uye enzim FonksiyonOksijen algilama tum aerobik organizmalarda homeostaz icin gereklidir Notrofil granulositlerdeki buyuk miktarlarda reaktif oksijen turlerinin ROS uretiminden sorumlu olana benzer bir fagosit tipi oksidazin bobrekte bobrek korteksindeki eritropoietin sentezini duzenleyen bir oksijen sensoru olarak islev gordugu ileri surulmustur Nox4 damar sistemini inflamatuvar strese karsi korur Amino endoperoksitler tarafindan Nox bagimli reaktif oksijen turu modulasyonu yuksek Nox4 eksprese eden kanser hucrelerinde apoptozu indukleyebilir Kaynakca a b Entrez Gene NOX4 NADPH oxidase 4 2 Kasim 2008 tarihinde kaynagindan Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase Circ Res 110 9 1217 25 Nisan 2012 doi 10 1161 CIRCRESAHA 112 267054 PMID 22456182 Nox4 dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells Cell Death Dis 4 3 e552 Mart 2013 doi 10 1038 cddis 2013 68 PMC 3615744 2 PMID 23519121 Konuyla ilgili yayinlarLachgar A Sojic N Arbault S ve digerleri 1999 Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1 immunosuppressive tat and gp160 proteins J Virol 73 2 1447 52 doi 10 1128 JVI 73 2 1447 1452 1999 PMC 103969 2 PMID 9882350 Geiszt M Kopp JB Varnai P Leto TL 2000 Identification of renox an NAD P H oxidase in kidney Proc Natl Acad Sci U S A 97 14 8010 4 doi 10 1073 pnas 130135897 PMC 16661 2 PMID 10869423 Shiose A Kuroda J Tsuruya K ve digerleri 2001 A novel superoxide producing NAD P H oxidase in kidney J Biol Chem 276 2 1417 23 doi 10 1074 jbc M007597200 PMID 11032835 Cheng G Cao Z Xu X ve digerleri 2001 Homologs of gp91phox cloning and tissue expression of Nox3 Nox4 and Nox5 Gene 269 1 2 131 40 doi 10 1016 S0378 1119 01 00449 8 PMID 11376945 Brar SS Kennedy TP Sturrock AB ve digerleri 2002 An NAD P H oxidase regulates growth and transcription in melanoma cells Am J Physiol Cell Physiol 282 6 C1212 24 doi 10 1152 ajpcell 00496 2001 PMID 11997235 Strausberg RL Feingold EA Grouse LH ve digerleri 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 doi 10 1073 pnas 242603899 PMC 139241 2 PMID 12477932 Kalinina N Agrotis A Tararak E ve digerleri 2002 Cytochrome b558 dependent NAD P H oxidase phox units in smooth muscle and macrophages of atherosclerotic lesions Arterioscler Thromb Vasc Biol 22 12 2037 43 doi 10 1161 01 ATV 0000040222 02255 0F PMID 12482831 Hilenski LL Clempus RE Quinn MT ve digerleri 2004 Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells Arterioscler Thromb Vasc Biol 24 4 677 83 doi 10 1161 01 ATV 0000112024 13727 2c PMID 14670934 Ota T Suzuki Y Nishikawa T ve digerleri 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Mahadev K Motoshima H Wu X ve digerleri 2004 The NAD P H oxidase homolog Nox4 modulates insulin stimulated generation of H2O2 and plays an integral role in insulin signal transduction Mol Cell Biol 24 5 1844 54 doi 10 1128 MCB 24 5 1844 1854 2004 PMC 350558 2 PMID 14966267 Chamulitrat W Stremmel W Kawahara T ve digerleri 2004 A constitutive NADPH oxidase like system containing gp91phox homologs in human keratinocytes J Invest Dermatol 122 4 1000 9 doi 10 1111 j 0022 202X 2004 22410 x PMID 15102091 Vaquero EC Edderkaoui M Pandol SJ ve digerleri 2004 Reactive oxygen species produced by NAD P H oxidase inhibit apoptosis in pancreatic cancer cells J Biol Chem 279 33 34643 54 doi 10 1074 jbc M400078200 PMID 15155719 Schwarzer C Machen TE Illek B Fischer H 2004 NADPH oxidase dependent acid production in airway epithelial cells J Biol Chem 279 35 36454 61 doi 10 1074 jbc M404983200 PMID 15210697 Guzik TJ Sadowski J Kapelak B ve digerleri 2005 Systemic regulation of vascular NAD P H oxidase activity and nox isoform expression in human arteries and veins Arterioscler Thromb Vasc Biol 24 9 1614 20 doi 10 1161 01 ATV 0000139011 94634 9d PMID 15256399 Ambasta RK Kumar P Griendling KK ve digerleri 2004 Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase J Biol Chem 279 44 45935 41 doi 10 1074 jbc M406486200 PMID 15322091 Park HS Jung HY Park EY ve digerleri 2004 Cutting edge direct interaction of TLR4 with NAD P H oxidase 4 isozyme is essential for lipopolysaccharide induced production of reactive oxygen species and activation of NF kappa B J Immunol 173 6 3589 93 doi 10 4049 jimmunol 173 6 3589 PMID 15356101 Gerhard DS Wagner L Feingold EA ve digerleri 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 2 PMID 15489334 Jana A Pahan K 2005 Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox regulated activation of neutral sphingomyelinase J Neurosci 24 43 9531 40 doi 10 1523 JNEUROSCI 3085 04 2004 PMC 1955476 2 PMID 15509740 Pedruzzi E Guichard C Ollivier V ve digerleri 2004 NAD P H oxidase Nox 4 mediates 7 ketocholesterol induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells Mol Cell Biol 24 24 10703 17 doi 10 1128 MCB 24 24 10703 10717 2004 PMC 533993 2 PMID 15572675 Djordjevic T BelAiba RS Bonello S ve digerleri 2005 Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells Arterioscler Thromb Vasc Biol 25 3 519 25 doi 10 1161 01 ATV 0000154279 98244 eb PMID 15618545