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NADPH oksidaz 2 veya sitokrom b(558) alt-birimi beta veya Sitokrom B-245 ağır zincir, insanlarda NOX2 geni (diğer adıyla CYBB geni) tarafından kodlanan bir proteindir. Bu protein, reaktif oksijen türlerini (ROS) oluşturan süper oksiti üreten bir enzimdir.
Fonksiyon
Nox2 veya Sitokrom b (-245), sitokrom b alfa (CYBA) ve beta (CYBB) zincirinden oluşur. Fagositlerin mikrobisidal oksidaz sisteminin birincil bileşeni olduğu düşünülür.
Nox2, NADPH oksidazın katalitik, zara bağlı alt birimidir. Flavositokrom b558 olarak bilinen heterodimeri oluşturan membrana sabitlenmiş p22 <i id="mwKA">phox'a</i> bağlanana kadar inaktiftir. Aktivasyondan sonra, düzenleyici alt birimler p67phox, p47phox, p40phox ve tipik bir Rac olan GTPaz, plazma membranı veya fagozomal membran üzerinde NADPH oksidaz oluşturmak için komplekse dahil edilir. Nox2'nin kendisi, iki hem grubunu bağlayan bir N-terminal transmembran domaininden ve FAD ve NADPH'ye bağlanabilen bir C-terminal domaininden oluşur.
Kanıtlar, bu proteinin aortik ark, torasik ve abdominal aortta aterosklerotik lezyon gelişiminde önemli bir rol oynadığını göstermiştir.
Etkileşimler
NoX2 Podosit TRPC6 kanalları ile doğrudan etkileşir.
Kaynakça
- ^ "Entrez Gene: CYBB cytochrome b-245, beta polypeptide (chronic granulomatous disease)". 2 Kasım 2008 tarihinde kaynağından .
- ^ "NADPH oxidases in Eukaryotes: red algae provide new hints!". Current Genetics. 49 (3): 190-204. Mart 2006. doi:10.1007/s00294-005-0044-z. (PMID) 16344959.
- ^ "Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes". BMC Evolutionary Biology. 7: 178. Eylül 2007. doi:10.1186/1471-2148-7-178. (PMC) 2121648 $2. (PMID) 17900370.
- ^ Aguirre (2010). "Nox enzymes from fungus to fly to fish and what they tell us about Nox function in mammals". Free Radical Biology and Medicine. 49 (9): 1342-1353. doi:10.1016/j.freeradbiomed.2010.07.027. (PMC) 2981133 $2. (PMID) 20696238.
- ^ Sorescu (2002). "Superoxide production and expression of nox family proteins in human atherosclerosis". Circulation. 105 (12): 1429-35. doi:10.1161/01.cir.0000012917.74432.66. (PMID) 11914250.
- ^ Chaubey (2013). "Nox2 is required for macrophage chemotaxis towards CSF-1". PLOS ONE. 8 (2): e54869. doi:10.1371/journal.pone.0054869. (PMC) 3562318 $2. (PMID) 23383302.
- ^ "NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex". American Journal of Physiology. Cell Physiology. 305 (9): C960-71. Kasım 2013. doi:10.1152/ajpcell.00191.2013. (PMID) 23948707.
Konuyla ilgili yayınlar
- Bolscher BG, de Boer M, de Klein A, Weening RS, Roos D (Haziran 1991). "Point mutations in the beta-subunit of cytochrome b558 leading to X-linked chronic granulomatous disease". Blood. 77 (11): 2482-7. doi:10.1182/blood.V77.11.2482.2482. (PMID) 1710153.
- Nong Y, Kandil O, Tobin EH, Rose RM, Remold HG (Ocak 1991). "The HIV core protein p24 inhibits interferon-gamma-induced increase of HLA-DR and cytochrome b heavy chain mRNA levels in the human monocyte-like cell line THP1". Cellular Immunology. 132 (1): 10-6. doi:10.1016/0008-8749(91)90002-S. (PMID) 1905983.
- Dinauer MC, Pierce EA, Bruns GA, Curnutte JT, Orkin SH (Kasım 1990). "Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease". The Journal of Clinical Investigation. 86 (5): 1729-37. doi:10.1172/JCI114898. (PMC) 296926 $2. (PMID) 2243141.
- Royer-Pokora B, Kunkel LM, Monaco AP, Goff SC, Newburger PE, Baehner RL, Cole FS, Curnutte JT, Orkin SH (1986). "Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location" (PDF). Nature. 322 (6074): 32-8. doi:10.1038/322032a0. hdl:2027.42/62926. (PMID) 2425263. 30 Mart 2012 tarihinde kaynağından (PDF).
- Dinauer MC, Curnutte JT, Rosen H, Orkin SH (Aralık 1989). "A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease". The Journal of Clinical Investigation. 84 (6): 2012-6. doi:10.1172/JCI114393. (PMC) 304086 $2. (PMID) 2556453.
- Dinauer MC, Orkin SH, Brown R, Jesaitis AJ, Parkos CA (1987). "The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex". Nature. 327 (6124): 717-20. doi:10.1038/327717a0. (PMID) 3600768.
- Teahan C, Rowe P, Parker P, Totty N, Segal AW (1987). "The X-linked chronic granulomatous disease gene codes for the beta-chain of cytochrome b-245". Nature. 327 (6124): 720-1. doi:10.1038/327720a0. (PMID) 3600769.
- Rabbani H, de Boer M, Ahlin A, Sundin U, Elinder G, Hammarström L, Palmblad J, Smith CI, Roos D (Ekim 1993). "A 40-base-pair duplication in the gp91-phox gene leading to X-linked chronic granulomatous disease". European Journal of Haematology. 51 (4): 218-22. doi:10.1111/j.1600-0609.1993.tb00634.x. (PMID) 7694872.
- Pollock JD, Williams DA, Gifford MA, Li LL, Du X, Fisherman J, Orkin SH, Doerschuk CM, Dinauer MC (Şubat 1995). "Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production". Nature Genetics. 9 (2): 202-9. doi:10.1038/ng0295-202. (PMID) 7719350.
- Ariga T, Sakiyama Y, Matsumoto S (Ekim 1994). "Two novel point mutations in the cytochrome b 558 heavy chain gene, detected in two Japanese patients with X-linked chronic granulomatous disease". Human Genetics. 94 (4): 441. doi:10.1007/BF00201609. (PMID) 7927345.
- Leto TL, Adams AG, de Mendez I (Ekim 1994). "Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets". Proceedings of the National Academy of Sciences of the United States of America. 91 (22): 10650-4. doi:10.1073/pnas.91.22.10650. (PMC) 45079 $2. (PMID) 7938008.
- Ariga T, Sakiyama Y, Tomizawa K, Imajoh-Ohmi S, Kanegasaki S, Matsumoto S (Haziran 1993). "A newly recognized point mutation in the cytochrome b558 heavy chain gene replacing alanine57 by glutamic acid, in a patient with cytochrome b positive X-linked chronic granulomatous disease". European Journal of Pediatrics. 152 (6): 469-72. doi:10.1007/BF01955051. (PMID) 8101486.
- Leusen JH, de Boer M, Bolscher BG, Hilarius PM, Weening RS, Ochs HD, Roos D, Verhoeven AJ (Mayıs 1994). "A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox". The Journal of Clinical Investigation. 93 (5): 2120-6. doi:10.1172/JCI117207. (PMC) 294341 $2. (PMID) 8182143.
- Meindl A, Carvalho MR, Herrmann K, Lorenz B, Achatz H, Lorenz B, Apfelstedt-Sylla E, Wittwer B, Ross M, Meitinger T (Aralık 1995). "A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa". Human Molecular Genetics. 4 (12): 2339-46. doi:10.1093/hmg/4.12.2339. (PMID) 8634708.
- Sathyamoorthy M, de Mendez I, Adams AG, Leto TL (Nisan 1997). "p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain". The Journal of Biological Chemistry. 272 (14): 9141-6. doi:10.1074/jbc.272.14.9141. (PMID) 9083043.
- Eklund EA, Kakar R (Nisan 1997). "Identification and characterization of TF1(phox), a DNA-binding protein that increases expression of gp91(phox) in PLB985 myeloid leukemia cells". The Journal of Biological Chemistry. 272 (14): 9344-55. doi:10.1074/jbc.272.14.9344. (PMID) 9083071.
- Jendrossek V, Ritzel A, Neubauer B, Heyden S, Gahr M (Şubat 1997). "An in-frame triplet deletion within the gp91-phox gene in an adult X-linked chronic granulomatous disease patient with residual NADPH-oxidase activity". European Journal of Haematology. 58 (2): 78-85. doi:10.1111/j.1600-0609.1997.tb00928.x. (PMID) 9111587.
- Rae J, Newburger PE, Dinauer MC, Noack D, Hopkins PJ, Kuruto R, Curnutte JT (Haziran 1998). "X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase". American Journal of Human Genetics. 62 (6): 1320-31. doi:10.1086/301874. (PMC) 1377153 $2. (PMID) 9585602.
- Ariga T, Furuta H, Cho K, Sakiyama Y (Temmuz 1998). "Genetic analysis of 13 families with X-linked chronic granulomatous disease reveals a low proportion of sporadic patients and a high proportion of sporadic carriers". Pediatric Research. 44 (1): 85-92. doi:10.1203/00006450-199807000-00014. (PMID) 9667376.
- Kumatori A, Faizunnessa NN, Suzuki S, Moriuchi T, Kurozumi H, Nakamura M (Ekim 1998). "Nonhomologous recombination between the cytochrome b558 heavy chain gene (CYBB) and LINE-1 causes an X-linked chronic granulomatous disease". Genomics. 53 (2): 123-8. doi:10.1006/geno.1998.5510. (PMID) 9790760.
Dış bağlantılar
- Medical Subject Headings gp91phox+protein,+human
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NADPH oksidaz 2 veya sitokrom b 558 alt birimi beta veya Sitokrom B 245 agir zincir insanlarda NOX2 geni diger adiyla CYBB geni tarafindan kodlanan bir proteindir Bu protein reaktif oksijen turlerini ROS olusturan super oksiti ureten bir enzimdir FonksiyonNox2 veya Sitokrom b 245 sitokrom b alfa CYBA ve beta CYBB zincirinden olusur Fagositlerin mikrobisidal oksidaz sisteminin birincil bileseni oldugu dusunulur Nox2 NADPH oksidazin katalitik zara bagli alt birimidir Flavositokrom b558 olarak bilinen heterodimeri olusturan membrana sabitlenmis p22 lt i id mwKA gt phox a lt i gt baglanana kadar inaktiftir Aktivasyondan sonra duzenleyici alt birimler p67phox p47phox p40phox ve tipik bir Rac olan GTPaz plazma membrani veya fagozomal membran uzerinde NADPH oksidaz olusturmak icin komplekse dahil edilir Nox2 nin kendisi iki hem grubunu baglayan bir N terminal transmembran domaininden ve FAD ve NADPH ye baglanabilen bir C terminal domaininden olusur Kanitlar bu proteinin aortik ark torasik ve abdominal aortta aterosklerotik lezyon gelisiminde onemli bir rol oynadigini gostermistir EtkilesimlerNoX2 Podosit TRPC6 kanallari ile dogrudan etkilesir Kaynakca Entrez Gene CYBB cytochrome b 245 beta polypeptide chronic granulomatous disease 2 Kasim 2008 tarihinde kaynagindan NADPH oxidases in Eukaryotes red algae provide new hints Current Genetics 49 3 190 204 Mart 2006 doi 10 1007 s00294 005 0044 z PMID 16344959 Molecular evolution of Phox related regulatory subunits for NADPH oxidase enzymes BMC Evolutionary Biology 7 178 Eylul 2007 doi 10 1186 1471 2148 7 178 PMC 2121648 2 PMID 17900370 Aguirre 2010 Nox enzymes from fungus to fly to fish and what they tell us about Nox function in mammals Free Radical Biology and Medicine 49 9 1342 1353 doi 10 1016 j freeradbiomed 2010 07 027 PMC 2981133 2 PMID 20696238 Sorescu 2002 Superoxide production and expression of nox family proteins in human atherosclerosis Circulation 105 12 1429 35 doi 10 1161 01 cir 0000012917 74432 66 PMID 11914250 Chaubey 2013 Nox2 is required for macrophage chemotaxis towards CSF 1 PLOS ONE 8 2 e54869 doi 10 1371 journal pone 0054869 PMC 3562318 2 PMID 23383302 NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol essential role of podocin in formation of this complex American Journal of Physiology Cell Physiology 305 9 C960 71 Kasim 2013 doi 10 1152 ajpcell 00191 2013 PMID 23948707 Konuyla ilgili yayinlarBolscher BG de Boer M de Klein A Weening RS Roos D Haziran 1991 Point mutations in the beta subunit of cytochrome b558 leading to X linked chronic granulomatous disease Blood 77 11 2482 7 doi 10 1182 blood V77 11 2482 2482 PMID 1710153 Nong Y Kandil O Tobin EH Rose RM Remold HG Ocak 1991 The HIV core protein p24 inhibits interferon gamma induced increase of HLA DR and cytochrome b heavy chain mRNA levels in the human monocyte like cell line THP1 Cellular Immunology 132 1 10 6 doi 10 1016 0008 8749 91 90002 S PMID 1905983 Dinauer MC Pierce EA Bruns GA Curnutte JT Orkin SH Kasim 1990 Human neutrophil cytochrome b light chain p22 phox Gene structure chromosomal location and mutations in cytochrome negative autosomal recessive chronic granulomatous disease The Journal of Clinical Investigation 86 5 1729 37 doi 10 1172 JCI114898 PMC 296926 2 PMID 2243141 Royer Pokora B Kunkel LM Monaco AP Goff SC Newburger PE Baehner RL Cole FS Curnutte JT Orkin SH 1986 Cloning the gene for an inherited human disorder chronic granulomatous disease on the basis of its chromosomal location PDF Nature 322 6074 32 8 doi 10 1038 322032a0 hdl 2027 42 62926 PMID 2425263 30 Mart 2012 tarihinde kaynagindan PDF Dinauer MC Curnutte JT Rosen H Orkin SH Aralik 1989 A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome positive X linked chronic granulomatous disease The Journal of Clinical Investigation 84 6 2012 6 doi 10 1172 JCI114393 PMC 304086 2 PMID 2556453 Dinauer MC Orkin SH Brown R Jesaitis AJ Parkos CA 1987 The glycoprotein encoded by the X linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex Nature 327 6124 717 20 doi 10 1038 327717a0 PMID 3600768 Teahan C Rowe P Parker P Totty N Segal AW 1987 The X linked chronic granulomatous disease gene codes for the beta chain of cytochrome b 245 Nature 327 6124 720 1 doi 10 1038 327720a0 PMID 3600769 Rabbani H de Boer M Ahlin A Sundin U Elinder G Hammarstrom L Palmblad J Smith CI Roos D Ekim 1993 A 40 base pair duplication in the gp91 phox gene leading to X linked chronic granulomatous disease European Journal of Haematology 51 4 218 22 doi 10 1111 j 1600 0609 1993 tb00634 x PMID 7694872 Pollock JD Williams DA Gifford MA Li LL Du X Fisherman J Orkin SH Doerschuk CM Dinauer MC Subat 1995 Mouse model of X linked chronic granulomatous disease an inherited defect in phagocyte superoxide production Nature Genetics 9 2 202 9 doi 10 1038 ng0295 202 PMID 7719350 Ariga T Sakiyama Y Matsumoto S Ekim 1994 Two novel point mutations in the cytochrome b 558 heavy chain gene detected in two Japanese patients with X linked chronic granulomatous disease Human Genetics 94 4 441 doi 10 1007 BF00201609 PMID 7927345 Leto TL Adams AG de Mendez I Ekim 1994 Assembly of the phagocyte NADPH oxidase binding of Src homology 3 domains to proline rich targets Proceedings of the National Academy of Sciences of the United States of America 91 22 10650 4 doi 10 1073 pnas 91 22 10650 PMC 45079 2 PMID 7938008 Ariga T Sakiyama Y Tomizawa K Imajoh Ohmi S Kanegasaki S Matsumoto S Haziran 1993 A newly recognized point mutation in the cytochrome b558 heavy chain gene replacing alanine57 by glutamic acid in a patient with cytochrome b positive X linked chronic granulomatous disease European Journal of Pediatrics 152 6 469 72 doi 10 1007 BF01955051 PMID 8101486 Leusen JH de Boer M Bolscher BG Hilarius PM Weening RS Ochs HD Roos D Verhoeven AJ Mayis 1994 A point mutation in gp91 phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47 phox and p67 phox The Journal of Clinical Investigation 93 5 2120 6 doi 10 1172 JCI117207 PMC 294341 2 PMID 8182143 Meindl A Carvalho MR Herrmann K Lorenz B Achatz H Lorenz B Apfelstedt Sylla E Wittwer B Ross M Meitinger T Aralik 1995 A gene SRPX encoding a sushi repeat containing protein is deleted in patients with X linked retinitis pigmentosa Human Molecular Genetics 4 12 2339 46 doi 10 1093 hmg 4 12 2339 PMID 8634708 Sathyamoorthy M de Mendez I Adams AG Leto TL Nisan 1997 p40 phox down regulates NADPH oxidase activity through interactions with its SH3 domain The Journal of Biological Chemistry 272 14 9141 6 doi 10 1074 jbc 272 14 9141 PMID 9083043 Eklund EA Kakar R Nisan 1997 Identification and characterization of TF1 phox a DNA binding protein that increases expression of gp91 phox in PLB985 myeloid leukemia cells The Journal of Biological Chemistry 272 14 9344 55 doi 10 1074 jbc 272 14 9344 PMID 9083071 Jendrossek V Ritzel A Neubauer B Heyden S Gahr M Subat 1997 An in frame triplet deletion within the gp91 phox gene in an adult X linked chronic granulomatous disease patient with residual NADPH oxidase activity European Journal of Haematology 58 2 78 85 doi 10 1111 j 1600 0609 1997 tb00928 x PMID 9111587 Rae J Newburger PE Dinauer MC Noack D Hopkins PJ Kuruto R Curnutte JT Haziran 1998 X Linked chronic granulomatous disease mutations in the CYBB gene encoding the gp91 phox component of respiratory burst oxidase American Journal of Human Genetics 62 6 1320 31 doi 10 1086 301874 PMC 1377153 2 PMID 9585602 Ariga T Furuta H Cho K Sakiyama Y Temmuz 1998 Genetic analysis of 13 families with X linked chronic granulomatous disease reveals a low proportion of sporadic patients and a high proportion of sporadic carriers Pediatric Research 44 1 85 92 doi 10 1203 00006450 199807000 00014 PMID 9667376 Kumatori A Faizunnessa NN Suzuki S Moriuchi T Kurozumi H Nakamura M Ekim 1998 Nonhomologous recombination between the cytochrome b558 heavy chain gene CYBB and LINE 1 causes an X linked chronic granulomatous disease Genomics 53 2 123 8 doi 10 1006 geno 1998 5510 PMID 9790760 Dis baglantilarMedical Subject Headings gp91phox protein human