Bu madde, ; zira herhangi bir maddeden bu maddeye verilmiş bir bağlantı yoktur.Eylül 2022) ( |
Karbonhidrat sülfotransferaz 1, insanlarda 11. kromozomun kısa kolunda bulunan CHST1 geni tarafından kodlanan bir proteindir. Proteinin polipeptit zincirinin uzunluğu 411 amino asittir ve molekül ağırlığı 46715'tir.
CHST1 | |||||||||||||||||||||||||
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Tanımlayıcılar | |||||||||||||||||||||||||
CHST1 | |||||||||||||||||||||||||
Dış kimlikler | OMIM: 603797 1924219 2711 CHST1 | ||||||||||||||||||||||||
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Türler | İnsan | Fare | |||||||||||||||||||||||
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RefSeq (mRNA) |
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RefSeq (protein) |
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Yerleşim (UCSC) | Krom. 11: 45.65 – 45.67 Mb | n/a | |||||||||||||||||||||||
PubMed araması | |||||||||||||||||||||||||
Vikiveri | |||||||||||||||||||||||||
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Proteinin kodlandığı gen, işlev bakımından transferazlara aittir. Enflamatuvar yanıt, karbonhidrat metabolizması gibi biyolojik süreçlerde etkinlik gösterir. Protein, golgi aygıtının zarında yerleşir.
Ayrıca bakınız
Kaynakça
- ^ a b c GRCh38: Ensembl release 89: ENSG00000175264 - , May 2017
- ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "HUGO Gene Nomenclature Commitee, HGNC:1969". Erişim tarihi: 8 Eylül 2017.[]
- ^ "UniProt, O43916". 27 Aralık 2016 tarihinde kaynağından . Erişim tarihi: 8 Eylül 2017.
Dış bağlantılar
- İnsan CHST130 Aralık 2019 tarihinde Wayback Machine sitesinde . genomunun yerleşimi ve CHST1[] geninin ayrıntıları UCSC Genom Tarayıcısı'nda.
Konuyla ilgili yayınlar
- Mazany K.D., Peng T., Watson C.E., Tabas I., Williams K.J. (1998). "Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization". Biochim. Biophys. Acta. Cilt 1407. s. 92 — 97. (PMID) 9639683 DOI:10.1016/S0925-4439(98)00028-3
- Li X., Tedder T.F. (1999). "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization". Genomics. Cilt 55. s. 345 — 347. (PMID) 10049591 DOI:10.1006/geno.1998.5653
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. Cilt 14. 2004. s. 2121 — 2127. (PMID) 15489334 DOI:10.1101/gr.2596504
- Torii T., Fukuta M., Habuchi O. (2000). "Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase". Glycobiology. Cilt 10. s. 203 — 211. (PMID) 10642612 DOI:10.1093/glycob/10.2.203
- Williams KJ (1997). "Atherosclerosis: cell biology and lipoproteins". Curr. Opin. Lipidol. 7 (6). ss. U202-8. doi:10.1097/00041433-199612000-00016. (PMID) 9117134.
- Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12). ss. 6953-9. (PMC) 240329 $2. (PMID) 1433500.
- Shilatifard A, Merkle RK, Helland DE (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2). ss. 943-52. (PMC) 237448 $2. (PMID) 8419650.
- Li X, Tedder TF (1999). "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization". Genomics. 55 (3). ss. 345-7. doi:10.1006/geno.1998.5653. (PMID) 10049591.
- Bistrup A, Bhakta S, Lee JK (1999). "Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin". J. Cell Biol. 145 (4). ss. 899-910. doi:10.1083/jcb.145.4.899. (PMC) 2133194 $2. (PMID) 10330415.
- Tu L, Murphy PG, Li X, Tedder TF (1999). "L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1". J. Immunol. 163 (9). ss. 5070-8. (PMID) 10528213.
- Torii T, Fukuta M, Habuchi O (2000). "Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase". Glycobiology. 10 (2). ss. 203-11. doi:10.1093/glycob/10.2.203. (PMID) 10642612.
- Li X, Tu L, Murphy PG (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin". J. Leukoc. Biol. 69 (4). ss. 565-74. (PMID) 11310842.
- Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15.000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26). ss. 16899-903. doi:10.1073/pnas.242603899. (PMC) 139241 $2. (PMID) 12477932.
- Yamada T, Ohtake S, Sato M, Habuchi O (2005). "Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues". Biochem. J. 384 (Pt 3). ss. 567-75. doi:10.1042/BJ20040965. (PMC) 1134142 $2. (PMID) 15324304.
- Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B). ss. 2121-7. doi:10.1101/gr.2596504. (PMC) 528928 $2. (PMID) 15489334.
- Rual JF, Venkatesan K, Hao T (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). ss. 1173-8. doi:10.1038/nature04209. (PMID) 16189514.
- Liu J, Chau CH, Liu H (2006). "Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth". J. Cell Sci. 119 (Pt 5). ss. 933-42. doi:10.1242/jcs.02796. (PMID) 16495484.
- Kitayama K, Hayashida Y, Nishida K, Akama TO (2007). "Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans". J. Biol. Chem. 282 (41). ss. 30085-96. doi:10.1074/jbc.M703695200. (PMID) 17690104.
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Bu madde oksuz maddedir zira herhangi bir maddeden bu maddeye verilmis bir baglanti yoktur Lutfen ilgili maddelerden bu sayfaya baglanti vermeye calisin Eylul 2022 Karbonhidrat sulfotransferaz 1 insanlarda 11 kromozomun kisa kolunda bulunan CHST1 geni tarafindan kodlanan bir proteindir Proteinin polipeptit zincirinin uzunlugu 411 amino asittir ve molekul agirligi 46715 tir CHST1TanimlayicilarCHST1Dis kimliklerOMIM 603797 1924219 2711 CHST1Gen yerlesimi Insan Krom 11 Kromozom insan Bant11p11 2Baslangic45 647 689 bcBitis45 665 622 bcRNA ekspresyonu deseniDaha cok ekspresyon verisi basvurusuGen ontolojisiMolekuler islevi transferase activity sulfotransferase activity N acetylglucosamine 6 O sulfotransferase activity keratan sulfotransferase activityHucresel bileseni Golgi membrane Golgi aygiti membrane integral component of membrane trans Golgi networkBiyolojik sureci sulfur compound metabolic process galactose metabolic process inflammatory response keratan sulfate biosynthetic process polysaccharide metabolic process keratan sulfate metabolic process carbohydrate metabolic process N acetylglucosamine metabolic processKaynaklar Amigo QuickGOTurlerInsanFare853476969ENSG00000175264ENSMUSG00000027221O43916Q9EQC0RefSeq mRNA NM 003654NM 023850 NM 001356552 NM 001356553RefSeq protein NP 003645NP 076339 NP 001343481 NP 001343482Yerlesim UCSC Krom 11 45 65 45 67 Mbn aPubMed aramasiVikiveriInsan i Gor DuzenleFare yi Gor Duzenle Proteinin kodlandigi gen islev bakimindan transferazlara aittir Enflamatuvar yanit karbonhidrat metabolizmasi gibi biyolojik sureclerde etkinlik gosterir Protein golgi aygitinin zarinda yerlesir Ayrica bakiniz11 kromozomKaynakca a b c GRCh38 Ensembl release 89 ENSG00000175264 May 2017 Insan PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Fare PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link HUGO Gene Nomenclature Commitee HGNC 1969 Erisim tarihi 8 Eylul 2017 olu kirik baglanti UniProt O43916 27 Aralik 2016 tarihinde kaynagindan Erisim tarihi 8 Eylul 2017 Dis baglantilarInsan CHST130 Aralik 2019 tarihinde Wayback Machine sitesinde genomunun yerlesimi ve CHST1 olu kirik baglanti geninin ayrintilari UCSC Genom Tarayicisi nda Konuyla ilgili yayinlarMazany K D Peng T Watson C E Tabas I Williams K J 1998 Human chondroitin 6 sulfotransferase cloning gene structure and chromosomal localization Biochim Biophys Acta Cilt 1407 s 92 97 KB1 bakim Birden fazla ad yazar listesi link PMID 9639683 DOI 10 1016 S0925 4439 98 00028 3 Li X Tedder T F 1999 CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells cDNA cloning expression and chromosomal localization Genomics Cilt 55 s 345 347 PMID 10049591 DOI 10 1006 geno 1998 5653 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res Cilt 14 2004 s 2121 2127 PMID 15489334 DOI 10 1101 gr 2596504 Torii T Fukuta M Habuchi O 2000 Sulfation of sialyl N acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal 6 sulfotransferase Glycobiology Cilt 10 s 203 211 KB1 bakim Birden fazla ad yazar listesi link PMID 10642612 DOI 10 1093 glycob 10 2 203 Williams KJ 1997 Atherosclerosis cell biology and lipoproteins Curr Opin Lipidol 7 6 ss U202 8 doi 10 1097 00041433 199612000 00016 PMID 9117134 Bernstein HB Compans RW 1992 Sulfation of the human immunodeficiency virus envelope glycoprotein J Virol 66 12 ss 6953 9 PMC 240329 2 PMID 1433500 Shilatifard A Merkle RK Helland DE 1993 Complex type N linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N acetylglucosamine J Virol 67 2 ss 943 52 PMC 237448 2 PMID 8419650 Li X Tedder TF 1999 CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells cDNA cloning expression and chromosomal localization Genomics 55 3 ss 345 7 doi 10 1006 geno 1998 5653 PMID 10049591 Bistrup A Bhakta S Lee JK 1999 Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L selectin J Cell Biol 145 4 ss 899 910 doi 10 1083 jcb 145 4 899 PMC 2133194 2 PMID 10330415 Tu L Murphy PG Li X Tedder TF 1999 L selectin ligands expressed by human leukocytes are HECA 452 antibody defined carbohydrate epitopes preferentially displayed by P selectin glycoprotein ligand 1 J Immunol 163 9 ss 5070 8 PMID 10528213 Torii T Fukuta M Habuchi O 2000 Sulfation of sialyl N acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal 6 sulfotransferase Glycobiology 10 2 ss 203 11 doi 10 1093 glycob 10 2 203 PMID 10642612 Li X Tu L Murphy PG 2001 CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear resistant leukocyte rolling via L selectin J Leukoc Biol 69 4 ss 565 74 PMID 11310842 Strausberg RL Feingold EA Grouse LH 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 ss 16899 903 doi 10 1073 pnas 242603899 PMC 139241 2 PMID 12477932 Yamada T Ohtake S Sato M Habuchi O 2005 Chondroitin 4 sulphotransferase 1 and chondroitin 6 sulphotransferase 1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues Biochem J 384 Pt 3 ss 567 75 doi 10 1042 BJ20040965 PMC 1134142 2 PMID 15324304 Gerhard DS Wagner L Feingold EA 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B ss 2121 7 doi 10 1101 gr 2596504 PMC 528928 2 PMID 15489334 Rual JF Venkatesan K Hao T 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 ss 1173 8 doi 10 1038 nature04209 PMID 16189514 Liu J Chau CH Liu H 2006 Upregulation of chondroitin 6 sulphotransferase 1 facilitates Schwann cell migration during axonal growth J Cell Sci 119 Pt 5 ss 933 42 doi 10 1242 jcs 02796 PMID 16495484 Kitayama K Hayashida Y Nishida K Akama TO 2007 Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans J Biol Chem 282 41 ss 30085 96 doi 10 1074 jbc M703695200 PMID 17690104