Bu madde, ; zira herhangi bir maddeden bu maddeye verilmiş bir bağlantı yoktur.Mayıs 2022) ( |
ADP-ribozillenme faktörü benzeri protein 2, insanlarda ARL2 geni tarafından kodlanan bir proteindir.
ARL2 | |||||||||||||||||||||||||
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Tanımlayıcılar | |||||||||||||||||||||||||
ARL2 | |||||||||||||||||||||||||
Dış kimlikler | OMIM: 601175 1928393 1260 ARL2 | ||||||||||||||||||||||||
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Türler | İnsan | Fare | |||||||||||||||||||||||
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RefSeq (mRNA) |
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RefSeq (protein) |
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Yerleşim (UCSC) | Krom. 11: 65.01 – 65.02 Mb | n/a | |||||||||||||||||||||||
PubMed araması | |||||||||||||||||||||||||
Vikiveri | |||||||||||||||||||||||||
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İşlev
ADP-ribozillenme faktörü (ARF) genleri, RAS süper ailesinin küçük GTP bağlayıcı proteinleridir. ARL2, ARF benzeri genlerin işlevsel olarak farklı bir grubunun bir üyesidir.
Etkileşimler
ARL2'nin Unc-119, TBCD ve PDE6D ile etkileşime girdiği gösterilmiştir.
Kaynakça
- ^ a b c GRCh38: Ensembl release 89: ENSG00000213465 - , May 2017
- ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes". Proc. Natl. Acad. Sci. U.S.A. 90 (19). Kasım 1993. ss. 8952-6.
- ^ "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res. 7 (7). Eylül 1997. ss. 725-35.
- ^ a b "Entrez Gene: ARL2 ADP-ribosylation factor-like 2". 5 Aralık 2010 tarihinde kaynağından .
- ^ "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1-3). Ocak 2003. ss. 26-32.
- ^ "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. 278 (42). Ekim 2003. ss. 40829-36.
- ^ "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5). Mayıs 2000. ss. 1087-96.
- ^ "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). Ekim 2005. ss. 1173-8.
- ^ "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9). Mayıs 2002. ss. 2095-106.
Dış bağlantılar
- Human ARL2 30 Aralık 2019 tarihinde Wayback Machine sitesinde . genome location and ARL2[] gene details page in the UCSC Genome Browser.
Konuyla ilgili yayınlar
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2). ss. 171-4. doi:10.1016/0378-1119(94)90802-8. (PMID) 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2). ss. 149-56. doi:10.1016/S0378-1119(97)00411-3. (PMID) 9373149.
- Bhamidipati A, Lewis SA, Cowan NJ (2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5). ss. 1087-96. doi:10.1083/jcb.149.5.1087. (PMC) 2174823 $2. (PMID) 10831612.
- Sharer JD, Shern JF, Van Valkenburgh H, Wallace DC, Kahn RA (2002). "ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter". Mol. Biol. Cell. 13 (1). ss. 71-83. doi:10.1091/mbc.01-05-0245. (PMC) 65073 $2. (PMID) 11809823.
- Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9). ss. 2095-106. doi:10.1093/emboj/21.9.2095. (PMC) 125981 $2. (PMID) 11980706.
- Antoshechkin I, Han M (2002). "The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis". Dev. Cell. 2 (5). ss. 579-91. doi:10.1016/S1534-5807(02)00146-6. (PMID) 12015966.
- Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G (2003). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1-3). ss. 26-32. doi:10.1016/S0014-5793(02)03766-3. (PMID) 12527357.
- Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. 278 (42). ss. 40829-36. doi:10.1074/jbc.M308678200. (PMID) 12912990.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). ss. 1173-8. doi:10.1038/nature04209. (PMID) 16189514.
- Zhou C, Cunningham L, Marcus AI, Li Y, Kahn RA (2006). "Arl2 and Arl3 regulate different microtubule-dependent processes". Mol. Biol. Cell. 17 (5). ss. 2476-87. doi:10.1091/mbc.E05-10-0929. (PMC) 1446103 $2. (PMID) 16525022.
- Beghin A, Honore S, Messana C, Matera EL, Aim J, Burlinchon S, Braguer D, Dumontet C (2007). "ADP ribosylation factor like 2 (Arl2) protein influences microtubule dynamics in breast cancer cells". Exp. Cell Res. 313 (3). ss. 473-85. doi:10.1016/j.yexcr.2006.10.024. (PMID) 17188265.
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Bu madde oksuz maddedir zira herhangi bir maddeden bu maddeye verilmis bir baglanti yoktur Lutfen ilgili maddelerden bu sayfaya baglanti vermeye calisin Mayis 2022 ADP ribozillenme faktoru benzeri protein 2 insanlarda ARL2 geni tarafindan kodlanan bir proteindir ARL2Uygun yapilarPDBOrtolog aramasi PDBe RCSBPDB kimlik kodlarinin listesi3DOE 3DOFTanimlayicilarARL2Dis kimliklerOMIM 601175 1928393 1260 ARL2Gen yerlesimi Insan Krom 11 Kromozom insan Bant11q13 1Baslangic65 014 160 bcBitis65 022 184 bcGen ontolojisiMolekuler islevi nucleotide binding GTP binding GTPase inhibitor activity GO 0001948 GO 0016582 protein baglanmasi GO 0006184 GTPase activity GDP bindingHucresel bileseni sitoplazma sentrozom lateral plasma membrane mitochondrial intermembrane space intracellular anatomical structure microtubule organizing center mitochondrial matrix mitokondri Hucre iskeleti hucre cekirdegi Cekirdekcik Golgi aygiti Sitozol focal adhesion Sil microtubule cytoskeletonBiyolojik sureci tubulin complex assembly regulation of insulin secretion GO 0034259 negative regulation of GTPase activity regulation of microtubule polymerization bicellular tight junction assembly positive regulation of microtubule polymerization Hucre dongusu maintenance of protein location in nucleus positive regulation of cell substrate adhesion centrosome cycleKaynaklar Amigo QuickGOTurlerInsanFare40256327ENSG00000213465ENSMUSG00000024944P36404Q9D0J4RefSeq mRNA NM 001667 NM 001199745NM 019722RefSeq protein NP 001186674 NP 001658NP 062696Yerlesim UCSC Krom 11 65 01 65 02 Mbn aPubMed aramasiVikiveriInsan i Gor DuzenleFare yi Gor DuzenleIslevADP ribozillenme faktoru ARF genleri RAS super ailesinin kucuk GTP baglayici proteinleridir ARL2 ARF benzeri genlerin islevsel olarak farkli bir grubunun bir uyesidir EtkilesimlerARL2 nin Unc 119 TBCD ve PDE6D ile etkilesime girdigi gosterilmistir Kaynakca a b c GRCh38 Ensembl release 89 ENSG00000213465 May 2017 Insan PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Fare PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Selective amplification of additional members of the ADP ribosylation factor ARF family cloning of additional human and Drosophila ARF like genes Proc Natl Acad Sci U S A 90 19 Kasim 1993 ss 8952 6 A transcript map for the 2 8 Mb region containing the multiple endocrine neoplasia type 1 locus Genome Res 7 7 Eylul 1997 ss 725 35 a b Entrez Gene ARL2 ADP ribosylation factor like 2 5 Aralik 2010 tarihinde kaynagindan Photoreceptor synaptic protein HRG4 UNC119 interacts with ARL2 via a putative conserved domain FEBS Lett 534 1 3 Ocak 2003 ss 26 32 Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A J Biol Chem 278 42 Ekim 2003 ss 40829 36 ADP ribosylation factor like protein 2 Arl2 regulates the interaction of tubulin folding cofactor D with native tubulin J Cell Biol 149 5 Mayis 2000 ss 1087 96 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 Ekim 2005 ss 1173 8 The complex of Arl2 GTP and PDE delta from structure to function EMBO J 21 9 Mayis 2002 ss 2095 106 Dis baglantilarHuman ARL2 30 Aralik 2019 tarihinde Wayback Machine sitesinde genome location and ARL2 olu kirik baglanti gene details page in the UCSC Genome Browser Konuyla ilgili yayinlarMaruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 ss 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 ss 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Bhamidipati A Lewis SA Cowan NJ 2000 ADP ribosylation factor like protein 2 Arl2 regulates the interaction of tubulin folding cofactor D with native tubulin J Cell Biol 149 5 ss 1087 96 doi 10 1083 jcb 149 5 1087 PMC 2174823 2 PMID 10831612 Sharer JD Shern JF Van Valkenburgh H Wallace DC Kahn RA 2002 ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter Mol Biol Cell 13 1 ss 71 83 doi 10 1091 mbc 01 05 0245 PMC 65073 2 PMID 11809823 Hanzal Bayer M Renault L Roversi P Wittinghofer A Hillig RC 2002 The complex of Arl2 GTP and PDE delta from structure to function EMBO J 21 9 ss 2095 106 doi 10 1093 emboj 21 9 2095 PMC 125981 2 PMID 11980706 Antoshechkin I Han M 2002 The C elegans evl 20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis Dev Cell 2 5 ss 579 91 doi 10 1016 S1534 5807 02 00146 6 PMID 12015966 Kobayashi A Kubota S Mori N McLaren MJ Inana G 2003 Photoreceptor synaptic protein HRG4 UNC119 interacts with ARL2 via a putative conserved domain FEBS Lett 534 1 3 ss 26 32 doi 10 1016 S0014 5793 02 03766 3 PMID 12527357 Shern JF Sharer JD Pallas DC Bartolini F Cowan NJ Reed MS Pohl J Kahn RA 2003 Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A J Biol Chem 278 42 ss 40829 36 doi 10 1074 jbc M308678200 PMID 12912990 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 ss 1173 8 doi 10 1038 nature04209 PMID 16189514 Zhou C Cunningham L Marcus AI Li Y Kahn RA 2006 Arl2 and Arl3 regulate different microtubule dependent processes Mol Biol Cell 17 5 ss 2476 87 doi 10 1091 mbc E05 10 0929 PMC 1446103 2 PMID 16525022 Beghin A Honore S Messana C Matera EL Aim J Burlinchon S Braguer D Dumontet C 2007 ADP ribosylation factor like 2 Arl2 protein influences microtubule dynamics in breast cancer cells Exp Cell Res 313 3 ss 473 85 doi 10 1016 j yexcr 2006 10 024 PMID 17188265