Bu madde, ; zira herhangi bir maddeden bu maddeye verilmiş bir bağlantı yoktur.Eylül 2022) ( |
T hücresi yüzey glikoproteini CD3 delta zinciri, CD3D geni tarafından kodlanan bir insan proteinidir.
CD3D | |||||||||||||||||||||||||
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Tanımlayıcılar | |||||||||||||||||||||||||
CD3D | |||||||||||||||||||||||||
Dış kimlikler | OMIM: 186790 88331 585 CD3D | ||||||||||||||||||||||||
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Türler | İnsan | Fare | |||||||||||||||||||||||
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RefSeq (mRNA) |
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RefSeq (protein) |
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Yerleşim (UCSC) | Krom. 11: 118.34 – 118.34 Mb | n/a | |||||||||||||||||||||||
PubMed araması | |||||||||||||||||||||||||
Vikiveri | |||||||||||||||||||||||||
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Etkileşimler
CD3D'nin CD8A ile etkileşime girdiği gösterilmiştir.
Ayrıca bakınız
- CD3 (immünoloji)
- Başkalaşım kümesi
Kaynakça
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167286 - , May 2017
- ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)". 5 Aralık 2010 tarihinde kaynağından .
- ^ Doucey (Jan 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5). Amerika Birleşik Devletleri. ss. 3257-64.
Konuyla ilgili yayınlar
- "Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain". Int. Immunol. 7 (8). 1996. ss. 1237-41.
- Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference". J. Cell. Physiol. 209 (3). ss. 695-700.
- "Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins". J. Exp. Med. 175 (4). 1992. ss. 1055-66.
- "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". Immunol. Lett. 33 (3). 1992. ss. 307-14.
- "The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes". EMBO J. 10 (4). 1991. ss. 903-12.
- "Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3". Int. Immunol. 3 (4). 1991. ss. 353-7.
- "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx". Cell. Immunol. 137 (1). 1991. ss. 1-13.
- "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6). 1991. ss. 2117-24.
- "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV". Folia Biol. (Praha). 36 (1). 1990. ss. 71-7.
- "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2). 1990. ss. 299-305.
- "Dephosphorylation of the human T lymphocyte CD3 antigen". Eur. J. Biochem. 181 (1). 1989. ss. 55-65.
- "Physical linkage of three CD3 genes on human chromosome 11". EMBO J. 6 (10). 1988. ss. 2953-7.
- "Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein". Nature. 314 (6011). 1985. ss. 542-4.
- "Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex". Proc. Natl. Acad. Sci. U.S.A. 83 (9). 1986. ss. 2944-8.
- "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family". Proc. Natl. Acad. Sci. U.S.A. 84 (21). 1987. ss. 7649-53.
- "T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells". EMBO J. 5 (6). 1986. ss. 1245-52.
- "Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex". Nature. 312 (5993). 1985. ss. 413-8.
- "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120". AIDS Res. Hum. Retroviruses. 9 (10). 1994. ss. 945-55. 17 Şubat 2020 tarihinde kaynağından . Erişim tarihi: 17 Şubat 2020.
- "An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex". Cell. Immunol. 156 (2). 1994. ss. 286-95.
Dış bağlantılar
- Human CD3D genome location and CD3D gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P04234 (T-cell surface glycoprotein CD3 delta chain) at the PDBe-KB.
- PDBe-KB 23 Temmuz 2019 tarihinde Wayback Machine sitesinde . provides an overview of all the structure information available in the PDB for Human T-cell surface glycoprotein CD3 delta chain (CD3D)
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Bu madde oksuz maddedir zira herhangi bir maddeden bu maddeye verilmis bir baglanti yoktur Lutfen ilgili maddelerden bu sayfaya baglanti vermeye calisin Eylul 2022 T hucresi yuzey glikoproteini CD3 delta zinciri CD3D geni tarafindan kodlanan bir insan proteinidir CD3DUygun yapilarPDBOrtolog aramasi PDBe RCSBPDB kimlik kodlarinin listesi1XIWTanimlayicilarCD3DDis kimliklerOMIM 186790 88331 585 CD3DGen yerlesimi Insan Krom 11 Kromozom insan Bant11q23 3Baslangic118 339 075 bcBitis118 342 705 bcRNA ekspresyonu deseniDaha cok ekspresyon verisi basvurusuGen ontolojisiMolekuler islevi GO 0001105 transcription coactivator activity protein heterodimerization activity transmembrane signaling receptor activity protein homodimerization activityHucresel bileseni membrane sitoplazma alpha beta T cell receptor complex integral component of membrane T cell receptor complex clathrin coated vesicle membrane Hucre zari external side of plasma membraneBiyolojik sureci GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II regulation of immune response T cell receptor signaling pathway T cell differentiation positive thymic T cell selection cell surface receptor signaling pathway membrane organization protein homooligomerization adaptive immune response immune system processKaynaklar Amigo QuickGOTurlerInsanFare91512500ENSG00000167286ENSMUSG00000032094P04234P04235RefSeq mRNA NM 001040651 NM 000732NM 013487RefSeq protein NP 000723 NP 001035741NP 038515Yerlesim UCSC Krom 11 118 34 118 34 Mbn aPubMed aramasiVikiveriInsan i Gor DuzenleFare yi Gor DuzenleEtkilesimlerCD3D nin CD8A ile etkilesime girdigi gosterilmistir Ayrica bakinizCD3 immunoloji Baskalasim kumesiKaynakca a b c GRCh38 Ensembl release 89 ENSG00000167286 May 2017 Insan PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Fare PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Entrez Gene CD3D CD3d molecule delta CD3 TCR complex 5 Aralik 2010 tarihinde kaynagindan Doucey Jan 2003 CD3 delta establishes a functional link between the T cell receptor and CD8 J Biol Chem 278 5 Amerika Birlesik Devletleri ss 3257 64 Konuyla ilgili yayinlar Composition of TCR CD3 complex in human intestinal intraepithelial lymphocytes lack of Fc epsilon RI gamma chain Int Immunol 7 8 1996 ss 1237 41 Li CJ 2007 Therapeutic biology checkpoint pathway activation therapy HIV Tat and transkingdom RNA interference J Cell Physiol 209 3 ss 695 700 Ontogeny of human natural killer NK cells fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon delta proteins J Exp Med 175 4 1992 ss 1055 66 The antigen specific induction of normal human lymphocytes in vitro is down regulated by a conserved HIV p24 epitope Immunol Lett 33 3 1992 ss 307 14 The CD3 gamma and CD3 delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR CD3 complexes EMBO J 10 4 1991 ss 903 12 Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3 Int Immunol 3 4 1991 ss 353 7 A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV 1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx Cell Immunol 137 1 1991 ss 1 13 Human immunodeficiency virus 1 glycoproteins gp120 and gp160 specifically inhibit the CD3 T cell antigen receptor phosphoinositide transduction pathway J Clin Invest 86 6 1991 ss 2117 24 Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV Folia Biol Praha 36 1 1990 ss 71 7 The implications of subunit interactions for the structure of the T cell receptor CD3 complex Eur J Immunol 20 2 1990 ss 299 305 Dephosphorylation of the human T lymphocyte CD3 antigen Eur J Biochem 181 1 1989 ss 55 65 Physical linkage of three CD3 genes on human chromosome 11 EMBO J 6 10 1988 ss 2953 7 Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3 T cell receptor glycoprotein Nature 314 6011 1985 ss 542 4 Exon intron organization of the genes coding for the delta chains of the human and murine T cell receptor T3 complex Proc Natl Acad Sci U S A 83 9 1986 ss 2944 8 Evolutionary relationship between the T3 chains of the T cell receptor complex and the immunoglobulin supergene family Proc Natl Acad Sci U S A 84 21 1987 ss 7649 53 T3 delta pre mRNA is transcribed from a non TATA promoter and is alternatively spliced in human T cells EMBO J 5 6 1986 ss 1245 52 Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T cell receptor complex Nature 312 5993 1985 ss 413 8 Costimulatory properties of the human CD4 molecule enhancement of CD3 induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120 AIDS Res Hum Retroviruses 9 10 1994 ss 945 55 17 Subat 2020 tarihinde kaynagindan Erisim tarihi 17 Subat 2020 An HIV p24 heptapeptide down regulates antigen specific responses in vitro interfering at the level of the T3 Ti complex Cell Immunol 156 2 1994 ss 286 95 Dis baglantilarHuman CD3D genome location and CD3D gene details page in the UCSC Genome Browser Overview of all the structural information available in the PDB for UniProt P04234 T cell surface glycoprotein CD3 delta chain at the PDBe KB PDBe KB 23 Temmuz 2019 tarihinde Wayback Machine sitesinde provides an overview of all the structure information available in the PDB for Human T cell surface glycoprotein CD3 delta chain CD3D