Bu madde, ; zira herhangi bir maddeden bu maddeye verilmiş bir bağlantı yoktur.Eylül 2022) ( |
Kolin kinaz alfa, insanlarda CHKA geni tarafından kodlanan bir enzimdir.
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Tanımlayıcılar | |||||||||||||||||||||||||
CHKA | |||||||||||||||||||||||||
Dış kimlikler | OMIM: 118491 107760 88575 CHKA | ||||||||||||||||||||||||
2.7.1.82 | |||||||||||||||||||||||||
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Türler | İnsan | Fare | |||||||||||||||||||||||
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RefSeq (mRNA) |
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RefSeq (protein) |
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Yerleşim (UCSC) | Krom. 11: 68.05 – 68.12 Mb | n/a | |||||||||||||||||||||||
PubMed araması | |||||||||||||||||||||||||
Vikiveri | |||||||||||||||||||||||||
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Fosfatidilkolin biyosentezi için ana yol, CDP-kolin yolu üzerinden gerçekleşir. Bu gen tarafından kodlanan protein, dizideki ilk enzimdir ve düzenleyici bir rol oynayabilir. Kodlanan protein ayrıca etanolaminin fosforilasyonunu katalize eder. Bu gen için farklı izoformları kodlayan iki transkript türevi bulunmuştur.
Melanositik hücrelerde CHKA gen dışa vurumu MITF tarafından düzenlenebilir.
Kaynakça
- ^ a b c GRCh38: Ensembl release 89: ENSG00000110721 - , May 2017
- ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation". FEBS Lett. 304 (2-3). Aug 1992. ss. 229-32.
- ^ "Structure and function of choline kinase isoforms in mammalian cells". Prog Lipid Res. 43 (3). Mar 2004. ss. 266-81.
- ^ a b "Entrez Gene: CHKA choline kinase alpha". 5 Aralık 2010 tarihinde kaynağından .
- ^ "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6). 2008. ss. 665-76.
Dış bağlantılar
- İnsan CHKA 30 Aralık 2019 tarihinde Wayback Machine sitesinde . genomu yerleşimi ve CHKA geni ayrıntıları UCSC Genom Tarayıcısında.
Konuyla ilgili yayınlar
- Spanner S, Ansell GB (1979). "Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat forebrain". Biochem. J. 178 (3). ss. 753-60. (PMC) 1186576 $2. (PMID) 36885.
- Spanner S, Ansell GB (1978). "Choline and ethanolamine kinase activity in the cytoplasm of nerve endings from rat forebrain". Adv. Exp. Med. Biol. Cilt 101. ss. 237-45. doi:10.1007/978-1-4615-9071-2_23. (PMID) 208357.
- Kaplan O, Cohen JS (1994). "Lymphocyte activation-31P magnetic resonance studies of energy metabolism and phospholipid pathways". ImmunoMethods. 4 (2). ss. 139-47. doi:10.1006/immu.1994.1015. (PMID) 8069533.
- Price DJ, Rivnay B, Fu Y (1997). "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes". J. Biol. Chem. 272 (9). ss. 5915-20. doi:10.1074/jbc.272.9.5915. (PMID) 9038210.
- Ross BM, Moszczynska A, Blusztajn JK (1997). "Phospholipid biosynthetic enzymes in human brain". Lipids. 32 (4). ss. 351-8. doi:10.1007/s11745-997-0044-x. (PMID) 9113621.
- Nakagami K, Uchida T, Ohwada S (1999). "Increased choline kinase activity and elevated phosphocholine levels in human colon cancer". Jpn. J. Cancer Res. 90 (4). ss. 419-24. doi:10.1111/j.1349-7006.1999.tb00764.x. (PMC) 5926083 $2. (PMID) 10363580.
- Ramírez de Molina A, Penalva V, Lucas L, Lacal JC (2002). "Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K". Oncogene. 21 (6). ss. 937-46. doi:10.1038/sj.onc.1205144. (PMID) 11840339.
- Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Lett. 517 (1-3). ss. 167-71. doi:10.1016/S0014-5793(02)02614-5. (PMID) 12062430.
- Ramírez de Molina A, Gutiérrez R, Ramos MA (2002). "Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy". Oncogene. 21 (27). ss. 4317-22. doi:10.1038/sj.onc.1205556. (PMID) 12082619.
- Ramírez de Molina A, Rodríguez-González A, Gutiérrez R (2002). "Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers". Biochem. Biophys. Res. Commun. 296 (3). ss. 580-3. doi:10.1016/S0006-291X(02)00920-8. (PMID) 12176020.
- Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15.000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26). ss. 16899-903. doi:10.1073/pnas.242603899. (PMC) 139241 $2. (PMID) 12477932.
- Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21.243 full-length human cDNAs". Nat. Genet. 36 (1). ss. 40-5. doi:10.1038/ng1285. (PMID) 14702039.
- Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B). ss. 2121-7. doi:10.1101/gr.2596504. (PMC) 528928 $2. (PMID) 15489334.
- Gallego-Ortega D, Ramirez De Molina A, Gutierrez R (2006). "Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer" (PDF). Int. J. Oncol. 29 (2). ss. 335-40. doi:10.3892/ijo.29.2.335. (PMID) 16820874. 20 Ağustos 2017 tarihinde kaynağından (PDF). Erişim tarihi: 8 Mart 2020.
- Enaw JO, Zhu H, Yang W (2007). "CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population". BMC Medicine. Cilt 4. s. 36. doi:10.1186/1741-7015-4-36. (PMC) 1770928 $2. (PMID) 17184542.
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Bu madde oksuz maddedir zira herhangi bir maddeden bu maddeye verilmis bir baglanti yoktur Lutfen ilgili maddelerden bu sayfaya baglanti vermeye calisin Eylul 2022 Kolin kinaz alfa insanlarda CHKA geni tarafindan kodlanan bir enzimdir CHKAUygun yapilarPDBOrtolog aramasi PDBe RCSBPDB kimlik kodlarinin listesi2CKO 2CKP 2CKQ 2I7Q 3F2R 3G15 3ZM9 4BR3 4CG8 4CG9 4CGA 4DA5 5AFV 5EQE 5EQP 5EQY 5FTGTanimlayicilarCHKADis kimliklerOMIM 118491 107760 88575 CHKA2 7 1 82Gen yerlesimi Insan Krom 11 Kromozom insan Bant11q13 2Baslangic68 052 859 bcBitis68 121 444 bcRNA ekspresyonu deseniDaha cok ekspresyon verisi basvurusuGen ontolojisiMolekuler islevi transferase activity nucleotide binding protein homodimerization activity cholinesterase activity signal transducer activity choline binding kinase activity ATP binding ethanolamine kinase activity choline kinase activityHucresel bileseni sitoplazma SitozolBiyolojik sureci lipid transport ethanolamine metabolic process choline metabolic process Protein fosforilasyonu lipid metabolism response to 3 methylcholanthrene phospholipid biosynthetic process response to toxic substance CDP choline pathway GO 0072468 Sinyal transduksiyonu phosphatidylcholine biosynthetic process phosphatidylethanolamine biosynthetic processKaynaklar Amigo QuickGOTurlerInsanFare111912660ENSG00000110721ENSMUSG00000024843P35790O54804RefSeq mRNA NM 001277 NM 212469 NM 001376219 NM 001376220 NM 001376221NM 001376222NM 001025566 NM 001271496 NM 013490RefSeq protein NP 001268 NP 997634 NP 001363148 NP 001363149 NP 001363150NP 001363151NP 001258425 NP 038518Yerlesim UCSC Krom 11 68 05 68 12 Mbn aPubMed aramasiVikiveriInsan i Gor DuzenleFare yi Gor Duzenle Fosfatidilkolin biyosentezi icin ana yol CDP kolin yolu uzerinden gerceklesir Bu gen tarafindan kodlanan protein dizideki ilk enzimdir ve duzenleyici bir rol oynayabilir Kodlanan protein ayrica etanolaminin fosforilasyonunu katalize eder Bu gen icin farkli izoformlari kodlayan iki transkript turevi bulunmustur Melanositik hucrelerde CHKA gen disa vurumu MITF tarafindan duzenlenebilir Kaynakca a b c GRCh38 Ensembl release 89 ENSG00000110721 May 2017 Insan PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Fare PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation FEBS Lett 304 2 3 Aug 1992 ss 229 32 Structure and function of choline kinase isoforms in mammalian cells Prog Lipid Res 43 3 Mar 2004 ss 266 81 a b Entrez Gene CHKA choline kinase alpha 5 Aralik 2010 tarihinde kaynagindan Novel MITF targets identified using a two step DNA microarray strategy Pigment Cell Melanoma Res 21 6 2008 ss 665 76 Dis baglantilarInsan CHKA 30 Aralik 2019 tarihinde Wayback Machine sitesinde genomu yerlesimi ve CHKA geni ayrintilari UCSC Genom Tarayicisinda Konuyla ilgili yayinlarSpanner S Ansell GB 1979 Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat forebrain Biochem J 178 3 ss 753 60 PMC 1186576 2 PMID 36885 Spanner S Ansell GB 1978 Choline and ethanolamine kinase activity in the cytoplasm of nerve endings from rat forebrain Adv Exp Med Biol Cilt 101 ss 237 45 doi 10 1007 978 1 4615 9071 2 23 PMID 208357 Kaplan O Cohen JS 1994 Lymphocyte activation 31P magnetic resonance studies of energy metabolism and phospholipid pathways ImmunoMethods 4 2 ss 139 47 doi 10 1006 immu 1994 1015 PMID 8069533 Price DJ Rivnay B Fu Y 1997 Direct association of Csk homologous kinase CHK with the diphosphorylated site Tyr568 570 of the activated c KIT in megakaryocytes J Biol Chem 272 9 ss 5915 20 doi 10 1074 jbc 272 9 5915 PMID 9038210 Ross BM Moszczynska A Blusztajn JK 1997 Phospholipid biosynthetic enzymes in human brain Lipids 32 4 ss 351 8 doi 10 1007 s11745 997 0044 x PMID 9113621 Nakagami K Uchida T Ohwada S 1999 Increased choline kinase activity and elevated phosphocholine levels in human colon cancer Jpn J Cancer Res 90 4 ss 419 24 doi 10 1111 j 1349 7006 1999 tb00764 x PMC 5926083 2 PMID 10363580 Ramirez de Molina A Penalva V Lucas L Lacal JC 2002 Regulation of choline kinase activity by Ras proteins involves Ral GDS and PI3K Oncogene 21 6 ss 937 46 doi 10 1038 sj onc 1205144 PMID 11840339 Dubois T Howell S Zemlickova E Aitken A 2002 Identification of casein kinase Ialpha interacting protein partners FEBS Lett 517 1 3 ss 167 71 doi 10 1016 S0014 5793 02 02614 5 PMID 12062430 Ramirez de Molina A Gutierrez R Ramos MA 2002 Increased choline kinase activity in human breast carcinomas clinical evidence for a potential novel antitumor strategy Oncogene 21 27 ss 4317 22 doi 10 1038 sj onc 1205556 PMID 12082619 Ramirez de Molina A Rodriguez Gonzalez A Gutierrez R 2002 Overexpression of choline kinase is a frequent feature in human tumor derived cell lines and in lung prostate and colorectal human cancers Biochem Biophys Res Commun 296 3 ss 580 3 doi 10 1016 S0006 291X 02 00920 8 PMID 12176020 Strausberg RL Feingold EA Grouse LH 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 ss 16899 903 doi 10 1073 pnas 242603899 PMC 139241 2 PMID 12477932 Ota T Suzuki Y Nishikawa T 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 ss 40 5 doi 10 1038 ng1285 PMID 14702039 Gerhard DS Wagner L Feingold EA 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B ss 2121 7 doi 10 1101 gr 2596504 PMC 528928 2 PMID 15489334 Gallego Ortega D Ramirez De Molina A Gutierrez R 2006 Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer PDF Int J Oncol 29 2 ss 335 40 doi 10 3892 ijo 29 2 335 PMID 16820874 20 Agustos 2017 tarihinde kaynagindan PDF Erisim tarihi 8 Mart 2020 Enaw JO Zhu H Yang W 2007 CHKA and PCYT1A gene polymorphisms choline intake and spina bifida risk in a California population BMC Medicine Cilt 4 s 36 doi 10 1186 1741 7015 4 36 PMC 1770928 2 PMID 17184542