Bu madde, ; zira herhangi bir maddeden bu maddeye verilmiş bir bağlantı yoktur.Mayıs 2022) ( |
Arfaptin 2, insanlarda ARFIP2 geni tarafından kodlanan bir proteindir.
ARFIP2 | |||||||||||||||||||||||||
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Tanımlayıcılar | |||||||||||||||||||||||||
ARFIP2, POR1, ADP ribozillenme faktörü etkileşimli protein 2, ADP ribozilasyon faktörü etkileşimli protein 2 | |||||||||||||||||||||||||
Dış kimlikler | OMIM: 601638 1924182 8234 ARFIP2 | ||||||||||||||||||||||||
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Türler | İnsan | Fare | |||||||||||||||||||||||
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RefSeq (mRNA) |
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RefSeq (protein) |
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Yerleşim (UCSC) | Krom. 11: 6.47 – 6.48 Mb | n/a | |||||||||||||||||||||||
PubMed araması | |||||||||||||||||||||||||
Vikiveri | |||||||||||||||||||||||||
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Etkileşimler
ARFIP2'nin Arf6, ARF3, ARF5 ve RAC1 ile etkileşime girdiği gösterilmiştir.
Konuyla ilgili yayınlar
- D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (Eylül 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17). ss. 5445-54. doi:10.1093/emboj/16.17.5445. (PMC) 1170175 $2. (PMID) 9312003.
- Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (Mayıs 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834). ss. 215-9. doi:10.1038/35075620. (PMID) 11346801.
- Shin OH, Exton JH (Ağustos 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5). ss. 1267-73. doi:10.1006/bbrc.2001.5330. (PMID) 11478794.
- Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C (Mart 2002). "Arfaptin 2 regulates the aggregation of mutant huntingtin protein". Nature Cell Biology. 4 (3). ss. 240-5. doi:10.1038/ncb761. (PMID) 11854752.
- Lu L, Hong W (Eylül 2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Molecular Biology of the Cell. 14 (9). ss. 3767-81. doi:10.1091/mbc.E03-01-0864. (PMC) 196566 $2. (PMID) 12972563.
- Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S (Haziran 2005). "Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment". The Journal of Biological Chemistry. 280 (23). ss. 22021-8. doi:10.1074/jbc.M407528200. (PMID) 15809304.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Ekim 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). ss. 1173-8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. (PMID) 16189514.
Dış bağlantılar
- Human ARFIP230 Aralık 2019 tarihinde Wayback Machine sitesinde . genome location and ARFIP2[] gene details page in the UCSC Genome Browser.
Kaynakça
- ^ a b c GRCh38: Ensembl release 89: ENSG00000132254 - , May 2017
- ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15). Ağustos 1996. ss. 3778-86.
- ^ a b "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9). Şubat 1997. ss. 5421-9.
- ^ "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)". 5 Aralık 2010 tarihinde kaynağından .
- ^ "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17). Eylül 1997. ss. 5445-54.
- ^ "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5). Ağustos 2001. ss. 1267-73.
- ^ "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834). Mayıs 2001. ss. 215-9.
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Bu madde oksuz maddedir zira herhangi bir maddeden bu maddeye verilmis bir baglanti yoktur Lutfen ilgili maddelerden bu sayfaya baglanti vermeye calisin Mayis 2022 Arfaptin 2 insanlarda ARFIP2 geni tarafindan kodlanan bir proteindir ARFIP2Uygun yapilarPDBOrtolog aramasi PDBe RCSBPDB kimlik kodlarinin listesi1I49 1I4D 1I4L 1I4T 4DCNTanimlayicilarARFIP2 POR1 ADP ribozillenme faktoru etkilesimli protein 2 ADP ribozilasyon faktoru etkilesimli protein 2Dis kimliklerOMIM 601638 1924182 8234 ARFIP2Gen yerlesimi Insan Krom 11 Kromozom insan Bant11p15 4Baslangic6 474 683 bcBitis6 481 479 bcRNA ekspresyonu deseniDaha cok ekspresyon verisi basvurusuGen ontolojisiMolekuler islevi phosphatidylinositol 4 phosphate binding protein domain specific binding GO 0001948 GO 0016582 protein baglanmasi GTP binding identical protein binding cadherin binding GTP dependent protein binding phospholipid bindingHucresel bileseni cell cortex trans Golgi network membrane Hucre zari ruffle Sitozol sitoplazmaBiyolojik sureci ruffle organization small GTPase mediated signal transduction actin cytoskeleton organization regulation of Arp2 3 complex mediated actin nucleation lamellipodium assembly intracellular protein transportKaynaklar Amigo QuickGOTurlerInsanFare2364776932ENSG00000132254ENSMUSG00000030881P53365Q8K221RefSeq mRNA NM 001242854 NM 001242855 NM 001242856 NM 012402NM 029802RefSeq protein NP 001229783 NP 001229784 NP 001229785 NP 036534 NP 001357335NP 001357337 NP 001357338 NP 001357340 NP 001357341 NP 001357342 NP 001363487 NP 001363488 NP 001363489 NP 001363490 NP 001363491 NP 001363492 NP 001363493NP 084078Yerlesim UCSC Krom 11 6 47 6 48 Mbn aPubMed aramasiVikiveriInsan i Gor DuzenleFare yi Gor DuzenleEtkilesimlerARFIP2 nin Arf6 ARF3 ARF5 ve RAC1 ile etkilesime girdigi gosterilmistir Konuyla ilgili yayinlarD Souza Schorey C Boshans RL McDonough M Stahl PD Van Aelst L Eylul 1997 A role for POR1 a Rac1 interacting protein in ARF6 mediated cytoskeletal rearrangements The EMBO Journal 16 17 ss 5445 54 doi 10 1093 emboj 16 17 5445 PMC 1170175 2 PMID 9312003 Tarricone C Xiao B Justin N Walker PA Rittinger K Gamblin SJ Smerdon SJ Mayis 2001 The structural basis of Arfaptin mediated cross talk between Rac and Arf signalling pathways Nature 411 6834 ss 215 9 doi 10 1038 35075620 PMID 11346801 Shin OH Exton JH Agustos 2001 Differential binding of arfaptin 2 POR1 to ADP ribosylation factors and Rac1 Biochemical and Biophysical Research Communications 285 5 ss 1267 73 doi 10 1006 bbrc 2001 5330 PMID 11478794 Peters PJ Ning K Palacios F Boshans RL Kazantsev A Thompson LM Woodman B Bates GP D Souza Schorey C Mart 2002 Arfaptin 2 regulates the aggregation of mutant huntingtin protein Nature Cell Biology 4 3 ss 240 5 doi 10 1038 ncb761 PMID 11854752 Lu L Hong W Eylul 2003 Interaction of Arl1 GTP with GRIP domains recruits autoantigens Golgin 97 and Golgin 245 p230 onto the Golgi Molecular Biology of the Cell 14 9 ss 3767 81 doi 10 1091 mbc E03 01 0864 PMC 196566 2 PMID 12972563 Rangone H Pardo R Colin E Girault JA Saudou F Humbert S Haziran 2005 Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ huntingtin induced toxicity by rescuing proteasome impairment The Journal of Biological Chemistry 280 23 ss 22021 8 doi 10 1074 jbc M407528200 PMID 15809304 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M Ekim 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 ss 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 Dis baglantilarHuman ARFIP230 Aralik 2019 tarihinde Wayback Machine sitesinde genome location and ARFIP2 olu kirik baglanti gene details page in the UCSC Genome Browser Kaynakca a b c GRCh38 Ensembl release 89 ENSG00000132254 May 2017 Insan PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Fare PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link a b Identification of a novel Rac1 interacting protein involved in membrane ruffling The EMBO Journal 15 15 Agustos 1996 ss 3778 86 a b Arfaptin 1 a putative cytosolic target protein of ADP ribosylation factor is recruited to Golgi membranes The Journal of Biological Chemistry 272 9 Subat 1997 ss 5421 9 Entrez Gene ARFIP2 ADP ribosylation factor interacting protein 2 arfaptin 2 5 Aralik 2010 tarihinde kaynagindan A role for POR1 a Rac1 interacting protein in ARF6 mediated cytoskeletal rearrangements The EMBO Journal 16 17 Eylul 1997 ss 5445 54 Differential binding of arfaptin 2 POR1 to ADP ribosylation factors and Rac1 Biochemical and Biophysical Research Communications 285 5 Agustos 2001 ss 1267 73 The structural basis of Arfaptin mediated cross talk between Rac and Arf signalling pathways Nature 411 6834 Mayis 2001 ss 215 9