Bu madde, ; zira herhangi bir maddeden bu maddeye verilmiş bir bağlantı yoktur.Eylül 2022) ( |
Hücre iskeletine bağlı protein 5, insanlarda CKAP5 geni tarafından kodlanan mikrotübüle bağlı bir proteindir.Xenopus'un XMAP215 proteininin homologudur ve ch-Tog olarak da bilinir.
CKAP5 | |||||||||||||||||||||||||
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Tanımlayıcılar | |||||||||||||||||||||||||
CKAP5, CHTOG, MSPS, TOG, TOGp, ch-TOG, hücre iskeleti ilişkili protein 5 | |||||||||||||||||||||||||
Dış kimlikler | OMIM: 611142 1923036 8844 CKAP5 | ||||||||||||||||||||||||
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Türler | İnsan | Fare | |||||||||||||||||||||||
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RefSeq (mRNA) |
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RefSeq (protein) |
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Yerleşim (UCSC) | Krom. 11: 46.74 – 46.85 Mb | n/a | |||||||||||||||||||||||
PubMed araması | |||||||||||||||||||||||||
Vikiveri | |||||||||||||||||||||||||
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Bunun, en az iki farklı rollere sahiptir iğ ipliği oluşumunda en az iki ayrı rolü vardır: MCAK (KIF2C) aracılığıyla depolimerizasyondan kinetokor mikrotübüllerini korur ve MCAK etkinliğinden bağımsız bir işlev olan sentrozomal mikrotübül birleştiriminde cH-Tog önemli bir rol oynar.
Etkileşimler
CKAP5'in TACC1 ile etkileşime girdiği gösterilmiştir.
Kaynakça
- ^ a b c GRCh38: Ensembl release 89: ENSG00000175216 - , May 2017
- ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1). Jul 1995. ss. 37-43.
- ^ "Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors". Eur. J. Biochem. 234 (2). Feb 1996. ss. 406-13.
- ^ "Entrez Gene: CKAP5 cytoskeleton associated protein 5". 5 Aralık 2010 tarihinde kaynağından .
- ^ "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Mol. Biol. Cell. 15 (4). 2004. ss. 1580-90.
- ^ "MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics". Mol. Cell. Biol. 28 (23). 2008. ss. 7199-211.
- ^ "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50). Nov 2003. ss. 8102-16.
- ^ "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1). Apr 2002. ss. 195-200.
Dış bağlantılar
- İnsan CKAP5 30 Aralık 2019 tarihinde Wayback Machine sitesinde . genomu yerleşimi ve CKAP5 geni ayrıntıları UCSC Genom Tarayıcısında.
Konuyla ilgili yayınlar
- Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW (2007). "Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans". J. Cell Sci. 120 (Pt 7). ss. 1278-87. doi:10.1242/jcs.000604. (PMID) 17376965.
- Kosturko LD, Maggipinto MJ, D'Sa C, Carson JH, Barbarese E (2005). "The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2". Mol. Biol. Cell. 16 (4). ss. 1938-47. doi:10.1091/mbc.E04-08-0709. (PMC) 1073673 $2. (PMID) 15703215.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33). ss. 12130-5. doi:10.1073/pnas.0404720101. (PMC) 514446 $2. (PMID) 15302935.
- Cassimeris L, Morabito J (2004). "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Mol. Biol. Cell. 15 (4). ss. 1580-90. doi:10.1091/mbc.E03-07-0544. (PMC) 379257 $2. (PMID) 14718566.
- Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50). ss. 8102-16. doi:10.1038/sj.onc.1206972. (PMID) 14603251.
- Gergely F, Draviam VM, Raff JW (2003). "The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells". Genes Dev. 17 (3). ss. 336-41. doi:10.1101/gad.245603. (PMC) 195983 $2. (PMID) 12569123.
- Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11). ss. 1773-84. doi:10.1101/gr.406902. (PMC) 187542 $2. (PMID) 12421765.
- Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1). ss. 195-200. doi:10.1042/0264-6021.3630195. (PMC) 1222467 $2. (PMID) 11903063.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9). ss. 791-806. doi:10.1101/gr.6.9.791. (PMID) 8889548.
- Nakamura S, Grigoriev I, Nogi T, Hamaji T, Cassimeris L, Mimori-Kiyosue Y (2012). "Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells". PLoS ONE. 7 (12). ss. e51442. doi:10.1371/journal.pone.0051442. (PMC) 3520847 $2. (PMID) 23251535.
- Zanic M, Widlund PO, Hyman AA, Howard J (2013). "Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels". Nat. Cell Biol. 15 (6). ss. 688-93. doi:10.1038/ncb2744. (PMID) 23666085.
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Bu madde oksuz maddedir zira herhangi bir maddeden bu maddeye verilmis bir baglanti yoktur Lutfen ilgili maddelerden bu sayfaya baglanti vermeye calisin Eylul 2022 Hucre iskeletine bagli protein 5 insanlarda CKAP5 geni tarafindan kodlanan mikrotubule bagli bir proteindir Xenopus un XMAP215 proteininin homologudur ve ch Tog olarak da bilinir CKAP5Uygun yapilarPDBOrtolog aramasi PDBe RCSBPDB kimlik kodlarinin listesi4QMI 4QMJTanimlayicilarCKAP5 CHTOG MSPS TOG TOGp ch TOG hucre iskeleti iliskili protein 5Dis kimliklerOMIM 611142 1923036 8844 CKAP5Gen yerlesimi Insan Krom 11 Kromozom insan Bant11p11 2Baslangic46 743 048 bcBitis46 846 308 bcRNA ekspresyonu deseniDaha cok ekspresyon verisi basvurusuGen ontolojisiMolekuler islevi GO 0001948 GO 0016582 protein baglanmasi cadherin binding microtubule plus end bindingHucresel bileseni sitoplazma Sitozol sentrozom spindle pole membrane microtubule cytoskeleton gamma tubulin complex microtubule organizing center microtubule plus end Hucre iskeleti Sentromer Kinetokor kromozom Ig iplikleri Cekirdekcik Hucre zari GO 0009327 protein containing complexBiyolojik sureci RNA transport establishment or maintenance of microtubule cytoskeleton polarity Hucre bolunmesi GO 0043146 spindle organization G2 M transition of mitotic cell cycle Hucre dongusu sister chromatid cohesion centrosome cycle microtubule polymerization centrosome duplication ciliary basal body plasma membrane docking regulation of G2 M transition of mitotic cell cycle microtubule depolymerizationKaynaklar Amigo QuickGOTurlerInsanFare979375786ENSG00000175216ENSMUSG00000040549Q14008A2AGT5RefSeq mRNA NM 014756 NM 001008938NM 001165989 NM 029437RefSeq protein NP 001008938 NP 055571NP 001159461 NP 083713Yerlesim UCSC Krom 11 46 74 46 85 Mbn aPubMed aramasiVikiveriInsan i Gor DuzenleFare yi Gor Duzenle Bunun en az iki farkli rollere sahiptir ig ipligi olusumunda en az iki ayri rolu vardir MCAK KIF2C araciligiyla depolimerizasyondan kinetokor mikrotubullerini korur ve MCAK etkinliginden bagimsiz bir islev olan sentrozomal mikrotubul birlestiriminde cH Tog onemli bir rol oynar EtkilesimlerCKAP5 in TACC1 ile etkilesime girdigi gosterilmistir Kaynakca a b c GRCh38 Ensembl release 89 ENSG00000175216 May 2017 Insan PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Fare PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Prediction of the coding sequences of unidentified human genes III The coding sequences of 40 new genes KIAA0081 KIAA0120 deduced by analysis of cDNA clones from human cell line KG 1 DNA Res 2 1 Jul 1995 ss 37 43 Characterization of the cDNA and pattern of expression of a new gene over expressed in human hepatomas and colonic tumors Eur J Biochem 234 2 Feb 1996 ss 406 13 Entrez Gene CKAP5 cytoskeleton associated protein 5 5 Aralik 2010 tarihinde kaynagindan TOGp the human homolog of XMAP215 Dis1 is required for centrosome integrity spindle pole organization and bipolar spindle assembly Mol Biol Cell 15 4 2004 ss 1580 90 MCAK independent functions of ch Tog XMAP215 in microtubule plus end dynamics Mol Cell Biol 28 23 2008 ss 7199 211 TACC1 chTOG Aurora A protein complex in breast cancer Oncogene 22 50 Nov 2003 ss 8102 16 Interaction of the transforming acidic coiled coil 1 TACC1 protein with ch TOG and GAS41 NuBI1 suggests multiple TACC1 containing protein complexes in human cells Biochem J 363 Pt 1 Apr 2002 ss 195 200 Dis baglantilarInsan CKAP5 30 Aralik 2019 tarihinde Wayback Machine sitesinde genomu yerlesimi ve CKAP5 geni ayrintilari UCSC Genom Tarayicisinda Konuyla ilgili yayinlarBasto R Gergely F Draviam VM Ohkura H Liley K Raff JW 2007 Hsp90 is required to localise cyclin B and Msps ch TOG to the mitotic spindle in Drosophila and humans J Cell Sci 120 Pt 7 ss 1278 87 doi 10 1242 jcs 000604 PMID 17376965 Kosturko LD Maggipinto MJ D Sa C Carson JH Barbarese E 2005 The microtubule associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2 Mol Biol Cell 16 4 ss 1938 47 doi 10 1091 mbc E04 08 0709 PMC 1073673 2 PMID 15703215 Beausoleil SA Jedrychowski M Schwartz D Elias JE Villen J Li J Cohn MA Cantley LC Gygi SP 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 101 33 ss 12130 5 doi 10 1073 pnas 0404720101 PMC 514446 2 PMID 15302935 Cassimeris L Morabito J 2004 TOGp the human homolog of XMAP215 Dis1 is required for centrosome integrity spindle pole organization and bipolar spindle assembly Mol Biol Cell 15 4 ss 1580 90 doi 10 1091 mbc E03 07 0544 PMC 379257 2 PMID 14718566 Conte N Delaval B Ginestier C Ferrand A Isnardon D Larroque C Prigent C Seraphin B Jacquemier J Birnbaum D 2003 TACC1 chTOG Aurora A protein complex in breast cancer Oncogene 22 50 ss 8102 16 doi 10 1038 sj onc 1206972 PMID 14603251 Gergely F Draviam VM Raff JW 2003 The ch TOG XMAP215 protein is essential for spindle pole organization in human somatic cells Genes Dev 17 3 ss 336 41 doi 10 1101 gad 245603 PMC 195983 2 PMID 12569123 Nakayama M Kikuno R Ohara O 2002 Protein protein interactions between large proteins two hybrid screening using a functionally classified library composed of long cDNAs Genome Res 12 11 ss 1773 84 doi 10 1101 gr 406902 PMC 187542 2 PMID 12421765 Lauffart B Howell SJ Tasch JE Cowell JK Still IH 2002 Interaction of the transforming acidic coiled coil 1 TACC1 protein with ch TOG and GAS41 NuBI1 suggests multiple TACC1 containing protein complexes in human cells Biochem J 363 Pt 1 ss 195 200 doi 10 1042 0264 6021 3630195 PMC 1222467 2 PMID 11903063 Bonaldo MF Lennon G Soares MB 1996 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 ss 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Nakamura S Grigoriev I Nogi T Hamaji T Cassimeris L Mimori Kiyosue Y 2012 Dissecting the nanoscale distributions and functions of microtubule end binding proteins EB1 and ch TOG in interphase HeLa cells PLoS ONE 7 12 ss e51442 doi 10 1371 journal pone 0051442 PMC 3520847 2 PMID 23251535 Zanic M Widlund PO Hyman AA Howard J 2013 Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels Nat Cell Biol 15 6 ss 688 93 doi 10 1038 ncb2744 PMID 23666085