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Rho GTPaz etkinleştirici protein 1, insanlarda ARHGAP1 geni tarafından kodlanan bir enzimdir.
ARHGAP1 | |||||||||||||||||||||||||
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ARHGAP1 | |||||||||||||||||||||||||
Dış kimlikler | OMIM: 602732 2445003 20909 ARHGAP1 | ||||||||||||||||||||||||
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Türler | İnsan | Fare | |||||||||||||||||||||||
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RefSeq (mRNA) |
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RefSeq (protein) |
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Yerleşim (UCSC) | Krom. 11: 46.68 – 46.7 Mb | n/a | |||||||||||||||||||||||
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Etkileşimler
Aşağıdakilerin ARHGAP1 ile etkileşime girdiği gösterilmiştir:
- BNIP2,
- CDC42 ve
- RHOA.
Konuyla ilgili yayınlar
- Diekmann D, Brill S, Garrett MD, Totty N, Hsuan J, Monfries C, Hall C, Lim L, Hall A (1991). "Bcr encodes a GTPase-activating protein for p21rac". Nature. 351 (6325). ss. 400-2. doi:10.1038/351400a0. (PMID) 1903516.
- Garrett MD, Major GN, Totty N, Hall A (1991). "Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP". Biochem. J. 276 (Pt 3) (3). ss. 833-6. (PMC) 1151079 $2. (PMID) 1905930.
- Barfod ET, Zheng Y, Kuang WJ, Hart MJ, Evans T, Cerione RA, Ashkenazi A (1993). "Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain". J. Biol. Chem. 268 (35). ss. 26059-62. (PMID) 8253717.
- Aspenström P, Lindberg U, Hall A (1996). "Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome". Curr. Biol. 6 (1). ss. 70-5. doi:10.1016/S0960-9822(02)00423-2. (PMID) 8805223.
- Barrett T, Xiao B, Dodson EJ, Dodson G, Ludbrook SB, Nurmahomed K, Gamblin SJ, Musacchio A, Smerdon SJ, Eccleston JF (1997). "The structure of the GTPase-activating domain from p50rhoGAP". Nature. 385 (6615). ss. 458-61. doi:10.1038/385458a0. (PMID) 9009196.
- Hu KQ, Settleman J (1997). "Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation". EMBO J. 16 (3). ss. 473-83. doi:10.1093/emboj/16.3.473. (PMC) 1169651 $2. (PMID) 9034330.
- Rittinger K, Walker PA, Eccleston JF, Nurmahomed K, Owen D, Laue E, Gamblin SJ, Smerdon SJ (1997). "Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP". Nature. 388 (6643). ss. 693-7. doi:10.1038/41805. (PMID) 9262406.
- Zhang B, Wang ZX, Zheng Y (1997). "Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains". J. Biol. Chem. 272 (35). ss. 21999-2007. doi:10.1074/jbc.272.35.21999. (PMID) 9268338.
- Li R, Zhang B, Zheng Y (1997). "Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190". J. Biol. Chem. 272 (52). ss. 32830-5. doi:10.1074/jbc.272.52.32830. (PMID) 9407060.
- Zhang B, Zheng Y (1998). "Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1". Biochemistry. 37 (15). ss. 5249-57. doi:10.1021/bi9718447. (PMID) 9548756.
- Low BC, Lim YP, Lim J, Wong ES, Guy GR (1999). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. 274 (46). ss. 33123-30. doi:10.1074/jbc.274.46.33123. (PMID) 10551883.
- Graham DL, Eccleston JF, Chung CW, Lowe PN (1999). "Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins". Biochemistry. 38 (45). ss. 14981-7. doi:10.1021/bi991358e. (PMID) 10555980.
- Low BC, Seow KT, Guy GR (2000). "Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2". J. Biol. Chem. 275 (19). ss. 14415-22. doi:10.1074/jbc.275.19.14415. (PMID) 10799524.
- Low BC, Seow KT, Guy GR (2000). "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. 275 (48). ss. 37742-51. doi:10.1074/jbc.M004897200. (PMID) 10954711.
- Zhou YT, Soh UJ, Shang X, Guy GR, Low BC (2002). "The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence". J. Biol. Chem. 277 (9). ss. 7483-92. doi:10.1074/jbc.M109459200. (PMID) 11741952.
- Fidyk NJ, Cerione RA (2002). "Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis". Biochemistry. 41 (52). ss. 15644-53. doi:10.1021/bi026413p. (PMID) 12501193.
- Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochem. Biophys. Res. Commun. 308 (2). ss. 379-85. doi:10.1016/S0006-291X(03)01387-1. (PMID) 12901880.
- Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46). ss. 45903-14. doi:10.1074/jbc.M304514200. (PMID) 12944407.
Dış bağlantılar
- Human ARHGAP1 30 Aralık 2019 tarihinde Wayback Machine sitesinde . genome location and ARHGAP1[] gene details page in the UCSC Genome Browser.
Kaynakça
- ^ a b c GRCh38: Ensembl release 89: ENSG00000175220 - , May 2017
- ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases". J. Biol. Chem. 269 (2). Şubat 1994. ss. 1137-42.
- ^ "Entrez Gene: ARHGAP1 Rho GTPase activating protein 1". 5 Aralık 2010 tarihinde kaynağından .
- ^ "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. 275 (48). Aralık 2000. ss. 37742-51.
- ^ "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. 274 (46). Kasım 1999. ss. 33123-30.
- ^ "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1). Ocak 1998. ss. 149-58.
- ^ "Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190". J. Biol. Chem. 272 (52). Aralık 1997. ss. 32830-5.
- ^ "Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA". J. Biol. Chem. 273 (15). Nisan 1998. ss. 8776-82.
- ^ "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). Ekim 2005. ss. 1173-8.
- ^ "Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1". Biochemistry. 37 (15). Nisan 1998. ss. 5249-57.
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Bu madde olmasi gerekenden az ic baglanti icermektedir veya hic icermemektedir Lutfen bu sayfadan ilgili maddelere ic baglanti vermeye calisin Eylul 2022 Bu madde oksuz maddedir zira herhangi bir maddeden bu maddeye verilmis bir baglanti yoktur Lutfen ilgili maddelerden bu sayfaya baglanti vermeye calisin Mayis 2022 Rho GTPaz etkinlestirici protein 1 insanlarda ARHGAP1 geni tarafindan kodlanan bir enzimdir ARHGAP1Uygun yapilarPDBOrtolog aramasi PDBe RCSBPDB kimlik kodlarinin listesi1AM4 1GRN 1OW3 1RGP 1TX4 2NGRTanimlayicilarARHGAP1Dis kimliklerOMIM 602732 2445003 20909 ARHGAP1Gen yerlesimi Insan Krom 11 Kromozom insan Bant11p11 2Baslangic46 677 080 bcBitis46 700 619 bcRNA ekspresyonu deseniDaha cok ekspresyon verisi basvurusuGen ontolojisiMolekuler islevi SH3 domain binding GO 0001948 GO 0016582 protein baglanmasi GO 0005097 GO 0005099 GO 0005100 GTPase activator activity cadherin bindingHucresel bileseni Sitozol extracellular exosome sitoplazma endosome membrane perinuclear region of cytoplasm sorting endosome membrane integral component of membraneBiyolojik sureci regulation of small GTPase mediated signal transduction Rho protein signal transduction GO 0072468 Sinyal transduksiyonu GO 0032320 GO 0032321 GO 0032855 GO 0043089 GO 0032854 positive regulation of GTPase activity small GTPase mediated signal transduction positive regulation of signal transduction transferrin transport iron ion import across cell outer membrane negative regulation of endocytic recycling endosomal transportKaynaklar Amigo QuickGOTurlerInsanFare392228359ENSG00000175220ENSMUSG00000027247Q07960Q5FWK3RefSeq mRNA NM 004308NM 001145902 NM 146124 NM 001359970RefSeq protein NP 004299NP 001139374 NP 666236 NP 001346899Yerlesim UCSC Krom 11 46 68 46 7 Mbn aPubMed aramasiVikiveriInsan i Gor DuzenleFare yi Gor DuzenleEtkilesimlerAsagidakilerin ARHGAP1 ile etkilesime girdigi gosterilmistir BNIP2 CDC42 ve RHOA Konuyla ilgili yayinlarDiekmann D Brill S Garrett MD Totty N Hsuan J Monfries C Hall C Lim L Hall A 1991 Bcr encodes a GTPase activating protein for p21rac Nature 351 6325 ss 400 2 doi 10 1038 351400a0 PMID 1903516 Garrett MD Major GN Totty N Hall A 1991 Purification and N terminal sequence of the p21rho GTPase activating protein rho GAP Biochem J 276 Pt 3 3 ss 833 6 PMC 1151079 2 PMID 1905930 Barfod ET Zheng Y Kuang WJ Hart MJ Evans T Cerione RA Ashkenazi A 1993 Cloning and expression of a human CDC42 GTPase activating protein reveals a functional SH3 binding domain J Biol Chem 268 35 ss 26059 62 PMID 8253717 Aspenstrom P Lindberg U Hall A 1996 Two GTPases Cdc42 and Rac bind directly to a protein implicated in the immunodeficiency disorder Wiskott Aldrich syndrome Curr Biol 6 1 ss 70 5 doi 10 1016 S0960 9822 02 00423 2 PMID 8805223 Barrett T Xiao B Dodson EJ Dodson G Ludbrook SB Nurmahomed K Gamblin SJ Musacchio A Smerdon SJ Eccleston JF 1997 The structure of the GTPase activating domain from p50rhoGAP Nature 385 6615 ss 458 61 doi 10 1038 385458a0 PMID 9009196 Hu KQ Settleman J 1997 Tandem SH2 binding sites mediate the RasGAP RhoGAP interaction a conformational mechanism for SH3 domain regulation EMBO J 16 3 ss 473 83 doi 10 1093 emboj 16 3 473 PMC 1169651 2 PMID 9034330 Rittinger K Walker PA Eccleston JF Nurmahomed K Owen D Laue E Gamblin SJ Smerdon SJ 1997 Crystal structure of a small G protein in complex with the GTPase activating protein rhoGAP Nature 388 6643 ss 693 7 doi 10 1038 41805 PMID 9262406 Zhang B Wang ZX Zheng Y 1997 Characterization of the interactions between the small GTPase Cdc42 and its GTPase activating proteins and putative effectors Comparison of kinetic properties of Cdc42 binding to the Cdc42 interactive domains J Biol Chem 272 35 ss 21999 2007 doi 10 1074 jbc 272 35 21999 PMID 9268338 Li R Zhang B Zheng Y 1997 Structural determinants required for the interaction between Rho GTPase and the GTPase activating domain of p190 J Biol Chem 272 52 ss 32830 5 doi 10 1074 jbc 272 52 32830 PMID 9407060 Zhang B Zheng Y 1998 Regulation of RhoA GTP hydrolysis by the GTPase activating proteins p190 p50RhoGAP Bcr and 3BP 1 Biochemistry 37 15 ss 5249 57 doi 10 1021 bi9718447 PMID 9548756 Low BC Lim YP Lim J Wong ES Guy GR 1999 Tyrosine phosphorylation of the Bcl 2 associated protein BNIP 2 by fibroblast growth factor receptor 1 prevents its binding to Cdc42GAP and Cdc42 J Biol Chem 274 46 ss 33123 30 doi 10 1074 jbc 274 46 33123 PMID 10551883 Graham DL Eccleston JF Chung CW Lowe PN 1999 Magnesium fluoride dependent binding of small G proteins to their GTPase activating proteins Biochemistry 38 45 ss 14981 7 doi 10 1021 bi991358e PMID 10555980 Low BC Seow KT Guy GR 2000 Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP 2 J Biol Chem 275 19 ss 14415 22 doi 10 1074 jbc 275 19 14415 PMID 10799524 Low BC Seow KT Guy GR 2000 The BNIP 2 and Cdc42GAP homology domain of BNIP 2 mediates its homophilic association and heterophilic interaction with Cdc42GAP J Biol Chem 275 48 ss 37742 51 doi 10 1074 jbc M004897200 PMID 10954711 Zhou YT Soh UJ Shang X Guy GR Low BC 2002 The BNIP 2 and Cdc42GAP homology Sec14p like domain of BNIP Salpha is a novel apoptosis inducing sequence J Biol Chem 277 9 ss 7483 92 doi 10 1074 jbc M109459200 PMID 11741952 Fidyk NJ Cerione RA 2002 Understanding the catalytic mechanism of GTPase activating proteins demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis Biochemistry 41 52 ss 15644 53 doi 10 1021 bi026413p PMID 12501193 Qin W Hu J Guo M Xu J Li J Yao G Zhou X Jiang H Zhang P Shen L Wan D Gu J 2003 BNIPL 2 a novel homologue of BNIP 2 interacts with Bcl 2 and Cdc42GAP in apoptosis Biochem Biophys Res Commun 308 2 ss 379 85 doi 10 1016 S0006 291X 03 01387 1 PMID 12901880 Shang X Zhou YT Low BC 2003 Concerted regulation of cell dynamics by BNIP 2 and Cdc42GAP homology Sec14p like proline rich and GTPase activating protein domains of a novel Rho GTPase activating protein BPGAP1 J Biol Chem 278 46 ss 45903 14 doi 10 1074 jbc M304514200 PMID 12944407 Dis baglantilarHuman ARHGAP1 30 Aralik 2019 tarihinde Wayback Machine sitesinde genome location and ARHGAP1 olu kirik baglanti gene details page in the UCSC Genome Browser Kaynakca a b c GRCh38 Ensembl release 89 ENSG00000175220 May 2017 Insan PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Fare PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Characterization of rhoGAP A GTPase activating protein for rho related small GTPases J Biol Chem 269 2 Subat 1994 ss 1137 42 Entrez Gene ARHGAP1 Rho GTPase activating protein 1 5 Aralik 2010 tarihinde kaynagindan The BNIP 2 and Cdc42GAP homology domain of BNIP 2 mediates its homophilic association and heterophilic interaction with Cdc42GAP J Biol Chem 275 48 Aralik 2000 ss 37742 51 Tyrosine phosphorylation of the Bcl 2 associated protein BNIP 2 by fibroblast growth factor receptor 1 prevents its binding to Cdc42GAP and Cdc42 J Biol Chem 274 46 Kasim 1999 ss 33123 30 The MAP kinase kinase kinase MLK2 co localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3 EMBO J 17 1 Ocak 1998 ss 149 58 Structural determinants required for the interaction between Rho GTPase and the GTPase activating domain of p190 J Biol Chem 272 52 Aralik 1997 ss 32830 5 Interaction of Rac1 with GTPase activating proteins and putative effectors A comparison with Cdc42 and RhoA J Biol Chem 273 15 Nisan 1998 ss 8776 82 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 Ekim 2005 ss 1173 8 Regulation of RhoA GTP hydrolysis by the GTPase activating proteins p190 p50RhoGAP Bcr and 3BP 1 Biochemistry 37 15 Nisan 1998 ss 5249 57