Azərbaycanca
Беларускі
Dansk
Deutsch
Española
Français
Indonesia
Italiana
日本語
Қазақ
Lietuvos
Nederlands
Português
Русский
සිංහල
แบบไทย
Türkçe
Українська
中國人
United State
Afrikaans
Eozinofil majör bazik proteini veya genellikle kısaltılmış olarak majör bazik protein (MBP; ayrıca Proteoglikan 2 (PRG2) olarak da adlandırılmaktadır), insanlarda PRG2 geni tarafından kodlanmaktadır.
| PRG2 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||||||||
| Tanımlayıcılar | |||||||||||||||||||||||||
| PRG2, BMPG, proMBP, MBP, MBP1, proteoglikan 2 - kemik iliği (öldürücü hücre aktivatörü, eozinofil granülü majör bazik proteini), proteoglikan 2 - pro-eozinofil major bazik proteini | |||||||||||||||||||||||||
| Dış kimlikler | OMIM: 605601 103294 2044 PRG2 | ||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| Türler | İnsan | Fare | |||||||||||||||||||||||
|
| ||||||||||||||||||||||||
|
| ||||||||||||||||||||||||
|
| ||||||||||||||||||||||||
| RefSeq (mRNA) |
|
| |||||||||||||||||||||||
| RefSeq (protein) |
|
| |||||||||||||||||||||||
| Yerleşim (UCSC) | Krom. 11: 57.39 – 57.39 Mb | n/a | |||||||||||||||||||||||
| PubMed araması | |||||||||||||||||||||||||
| Vikiveri | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
İşlev
Bu gen tarafından kodlanan protein, eozinofil granülünün kristal çekirdeğinin baskın bir bileşenidir. Bu proteinin proformu, plasenta ve gebelik serumunda da yüksek düzeyde bulunur, burada gebelikle ilişkili plazma proteini A (PAPPA), anjiyotensinojen (AGT) ve C3dg de içinde olmak üzere diğer birçok proteinle kompleks halinde bulunur. Bu protein, sitotoksin ve helmint toksini olarak antiparazitik savunma mekanizmalarına ve immün aşırıduyarlılık tepkimelerine girebilir. Alerji hastalıklarında epitelyal hücre hasarı, ve ile doğrudan ilişkilidir.
PRG2, eozinofil granüllerinde baskın olan 117-kalıntı proteinidir. Helmintlere karşı etkili bir enzimdir ve in vitro bakteri ve memeli hücrelerine karşı toksiktir. Eozinofil majör bazik protein ayrıca mast hücrelerinden ve bazofillerden histamin salınmasını sağlar ve nötrofiller ile alveoler makrofajları etkinleştirir.
Yapı
Yapısal olarak majör bazik protein, (şeker bağlayıcı proteinler) ile benzerdir ve C tipi lektinlerde görülene benzer bir katlantıya sahiptir. Bununla birlikte diğer C tipi lektinlerden (bunlar, kalsiyum varlığında çeşitli karbonhidratları bağlayanlardır) farklı olarak MPB, kalsiyumu veya bu ailenin tanıdığı diğer karbonhidratların hiçbirini bağlamaz.
Bunun yerine MBP, proteoglikanlarını tanır. MBP'nin iki kristalografik yapısı belirlenmiştir.
Etkileşimler
Majör bazik proteinin gebelik ile ilişkili plazma proteini A ile etkileşime girdiği gösterilmiştir.
Ayrıca bakınız
Kaynakça
- ^ a b c GRCh38: Ensembl release 89: ENSG00000186652 - , May 2017
- ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)". 2 Kasım 2008 tarihinde kaynağından .
- ^ PDB: 1h8u; "Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity". J. Biol. Chem. 276 (28). Temmuz 2001. ss. 26197-26203.
- ^ PDB: 2brs; "Eosinophil-granule major basic protein, a C-type lectin, binds heparin". Biochemistry. 44 (43). Kasım 2005. ss. 14152-14158.
- ^ Overgaard (Ekim 2000). "Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor". J. Biol. Chem. 275 (40). Amerika Birleşik Devletleri. ss. 31128-31133.
- ^ "Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment". J. Biol. Chem. 278 (4). Amerika Birleşik Devletleri. Ocak 2003. ss. 2106-2117.
- ^ Oxvig (Haziran 1993). "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein". J. Biol. Chem. 268 (17). Amerika Birleşik Devletleri. ss. 12243-6.
Konuyla ilgili yayınlar
- Vanhaesebroeck B, Alessi DR (2000). "The PI3K-PDK1 connection: more than just a road to PKB". Biochem. J. 346 (3). ss. 561-76. doi:10.1042/0264-6021.3460561. (PMC) 1220886 $2. (PMID) 10698680.
- Yoshimatsu K, Ohya Y, Shikata Y, Toshio S, Yoshikazu H, Isao T, Tamio K, Kyousuke K, Satoshi T (1992). "Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins". Mol. Immunol. 29 (4). ss. 537-546. doi:10.1016/0161-5890(92)90012-M. (PMID) 1565101.
- Barker RL, Loegering DA, Arakawa KC, Pease LR, Gleich GJ (1990). "Cloning and sequence analysis of the human gene encoding eosinophil major basic protein". Gene. 86 (2). ss. 285-289. doi:10.1016/0378-1119(90)90292-Y. (PMID) 2323577.
- Gabay JE, Scott RW, Campanelli D, Griffith J, Wilde C, Marra MN, Seeger M, Nathan CF (1989). "Antibiotic proteins of human polymorphonuclear leukocytes". Proc. Natl. Acad. Sci. U.S.A. 86 (14). ss. 5610-5614. Bibcode:1989PNAS...86.5610G. doi:10.1073/pnas.86.14.5610. (PMC) 297672 $2. (PMID) 2501794.
- Wasmoen TL, McKean DJ, Benirschke K, Coulam CB, Gleich GJ (1990). "Evidence of eosinophil granule major basic protein in human placenta". J. Exp. Med. 170 (6). ss. 2051-2063. doi:10.1084/jem.170.6.2051. (PMC) 2189540 $2. (PMID) 2584934.
- Barker RL, Gleich GJ, Pease LR (1988). "Acidic precursor revealed in human eosinophil granule major basic protein cDNA". J. Exp. Med. 168 (4). ss. 1493-1498. doi:10.1084/jem.168.4.1493. (PMC) 2189086 $2. (PMID) 3171483.
- McGrogan M, Simonsen C, Scott R, Griffith J, Ellis N, Kennedy J, Campanelli D, Nathan C, Gabay J (1989). "Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein". J. Exp. Med. 168 (6). ss. 2295-2308. doi:10.1084/jem.168.6.2295. (PMC) 2189145 $2. (PMID) 3199069.
- Wasmoen TL, Bell MP, Loegering DA, Gleich GJ, Prendergast FG, McKean DJ (1988). "Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein". J. Biol. Chem. 263 (25). ss. 12559-63. (PMID) 3410852.
- Weller PF, Ackerman SJ, Smith JA (1988). "Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase". J. Leukoc. Biol. 43 (1). ss. 1-4. doi:10.1002/jlb.43.1.1. (PMID) 3422083.
- Kristensen T, Oxvig C, Sand O, Hundahl Moeller NP, Sottrup-Jensen L (1994). "Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA". Biochemistry. 33 (6). ss. 1592-1598. doi:10.1021/bi00172a040. (PMID) 7508748.
- Oxvig C, Haaning J, Højrup P, Sottrup-Jensen L (1994). "Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum". Biochem. Mol. Biol. Int. 33 (2). ss. 329-36. (PMID) 7524900.
- Bonno M, Oxvig C, Kephart GM, Wagner JM, Kristensen T, Sottrup-Jensen L, Gleich GJ (1994). "Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta". Lab. Invest. 71 (4). ss. 560-6. (PMID) 7526035.
- Li MS, Sun L, Satoh T, Fisher LM, Spry CJ (1995). "Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters". Biochem. J. 305 (3). ss. 921-7. doi:10.1042/bj3050921. (PMC) 1136346 $2. (PMID) 7531438.
- Oxvig C, Haaning J, Kristensen L, Wagner JM, Rubin I, Stigbrand T, Gleich GJ, Sottrup-Jensen L (1995). "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma". J. Biol. Chem. 270 (23). ss. 13645-13651. doi:10.1074/jbc.270.23.13645
![image]()
. (PMID) 7539791. - Oxvig C, Sand O, Kristensen T, Gleich GJ, Sottrup-Jensen L (1993). "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein". J. Biol. Chem. 268 (17). ss. 12243-6. (PMID) 7685339.
- Levi-Schaffer F, Lacy P, Severs NJ, Newman TM, North J, Gomperts B, Kay AB, Moqbel R (1995). "Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophils". Blood. 85 (9). ss. 2579-86. doi:10.1182/blood.V85.9.2579.bloodjournal8592579
![image]()
. (PMID) 7727786. - Oxvig C, Gleich GJ, Sottrup-Jensen L (1994). "Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein" (PDF). FEBS Lett. 341 (2-3). ss. 213-217. doi:10.1016/0014-5793(94)80459-1. (PMID) 8137941. 22 Eylül 2017 tarihinde kaynağından (PDF). Erişim tarihi: 9 Mayıs 2020.
- Shikata Y, Hayashi Y, Yoshimatsu K, Ohya Y, Seto T, Fukushima K, Yoshida Y (1993). "Pro-major basic protein has three types of sugar chains at the pro-portion". Biochim. Biophys. Acta. 1163 (3). ss. 243-9. doi:10.1016/0167-4838(93)90158-N. (PMID) 8507662.
- Nittoh T, Watanabe M, Okayama H, Misawa S, Isobe Y, Hayashi H, Mue S, Ohuchi K (1996). "Cloning of cDNA for rat eosinophil major basic protein". Biochim. Biophys. Acta. 1264 (3). ss. 261-4. doi:10.1016/0167-4781(95)00183-2. (PMID) 8547309.
- Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S (1998). "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase". Proc. Natl. Acad. Sci. U.S.A. 95 (19). ss. 11211-11216. Bibcode:1998PNAS...9511211D. doi:10.1073/pnas.95.19.11211. (PMC) 21621 $2. (PMID) 9736715.
Dış bağlantılar
- Medical Subject Headings Eosinophil+Major+Basic+Protein
- PDBe-KB üzerinde PDB'de UniProt: P13727 (kemik iliği proteoglikanı) için uygun bütün yapısal bilgilere bir bakış.
wikipedia, wiki, viki, vikipedia, oku, kitap, kütüphane, kütübhane, ara, ara bul, bul, herşey, ne arasanız burada,hikayeler, makale, kitaplar, öğren, wiki, bilgi, tarih, yukle, izle, telefon için, turk, türk, türkçe, turkce, nasıl yapılır, ne demek, nasıl, yapmak, yapılır, indir, ücretsiz, ücretsiz indir, bedava, bedava indir, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, resim, müzik, şarkı, film, film, oyun, oyunlar, mobil, cep telefonu, telefon, android, ios, apple, samsung, iphone, xiomi, xiaomi, redmi, honor, oppo, nokia, sonya, mi, pc, web, computer, bilgisayar
Eozinofil major bazik proteini veya genellikle kisaltilmis olarak major bazik protein MBP ayrica Proteoglikan 2 PRG2 olarak da adlandirilmaktadir insanlarda PRG2 geni tarafindan kodlanmaktadir PRG2Uygun yapilarPDBOrtolog aramasi PDBe RCSBPDB kimlik kodlarinin listesi1H8U 2BRS 4QXXTanimlayicilarPRG2 BMPG proMBP MBP MBP1 proteoglikan 2 kemik iligi oldurucu hucre aktivatoru eozinofil granulu major bazik proteini proteoglikan 2 pro eozinofil major bazik proteiniDis kimliklerOMIM 605601 103294 2044 PRG2Gen yerlesimi Insan Krom 11 Kromozom insan Bant11q12 1Baslangic57 386 780 bcBitis57 390 650 bcRNA ekspresyonu deseniDaha cok ekspresyon verisi basvurusuGen ontolojisiMolekuler islevi heparin binding carbohydrate binding extracellular matrix structural constituent conferring compression resistanceHucresel bileseni extracellular region transport vesicle GO 0016023 cytoplasmic vesicle extracellular exosome ficolin 1 rich granule lumen collagen containing extracellular matrixBiyolojik sureci defense response to bacterium immune system process defense response to nematode negative regulation of interleukin 10 production positive regulation of interleukin 4 production GO 0046730 GO 0046737 GO 0046738 GO 0046736 Bagisiklik yaniti neutrophil degranulationKaynaklar Amigo QuickGOTurlerInsanFare555319074ENSG00000186652ENSMUSG00000027073P13727Q61878RefSeq mRNA NM 002728 NM 001243245 NM 001302926 NM 001302927NM 008920RefSeq protein NP 001230174 NP 001289855 NP 001289856 NP 002719NP 032946Yerlesim UCSC Krom 11 57 39 57 39 Mbn aPubMed aramasiVikiveriInsan i Gor DuzenleFare yi Gor DuzenleIslevBu gen tarafindan kodlanan protein eozinofil granulunun kristal cekirdeginin baskin bir bilesenidir Bu proteinin proformu plasenta ve gebelik serumunda da yuksek duzeyde bulunur burada gebelikle iliskili plazma proteini A PAPPA anjiyotensinojen AGT ve C3dg de icinde olmak uzere diger bircok proteinle kompleks halinde bulunur Bu protein sitotoksin ve helmint toksini olarak antiparazitik savunma mekanizmalarina ve immun asiriduyarlilik tepkimelerine girebilir Alerji hastaliklarinda epitelyal hucre hasari ve ile dogrudan iliskilidir PRG2 eozinofil granullerinde baskin olan 117 kalinti proteinidir Helmintlere karsi etkili bir enzimdir ve in vitro bakteri ve memeli hucrelerine karsi toksiktir Eozinofil major bazik protein ayrica mast hucrelerinden ve bazofillerden histamin salinmasini saglar ve notrofiller ile alveoler makrofajlari etkinlestirir YapiYapisal olarak major bazik protein seker baglayici proteinler ile benzerdir ve C tipi lektinlerde gorulene benzer bir katlantiya sahiptir Bununla birlikte diger C tipi lektinlerden bunlar kalsiyum varliginda cesitli karbonhidratlari baglayanlardir farkli olarak MPB kalsiyumu veya bu ailenin tanidigi diger karbonhidratlarin hicbirini baglamaz Bunun yerine MBP proteoglikanlarini tanir MBP nin iki kristalografik yapisi belirlenmistir EtkilesimlerMajor bazik proteinin gebelik ile iliskili plazma proteini A ile etkilesime girdigi gosterilmistir Ayrica bakinizKaynakca a b c GRCh38 Ensembl release 89 ENSG00000186652 May 2017 Insan PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link Fare PubMed Basvurusu National Center for Biotechnology Information U S National Library of Medicine Arsivlenmesi gereken baglantiya sahip kaynak sablonu iceren maddeler link a b Entrez Gene PRG2 proteoglycan 2 bone marrow natural killer cell activator eosinophil granule major basic protein 2 Kasim 2008 tarihinde kaynagindan PDB 1h8u Crystal structure of the eosinophil major basic protein at 1 8 A An atypical lectin with a paradigm shift in specificity J Biol Chem 276 28 Temmuz 2001 ss 26197 26203 PDB 2brs Eosinophil granule major basic protein a C type lectin binds heparin Biochemistry 44 43 Kasim 2005 ss 14152 14158 Overgaard Ekim 2000 Expression of recombinant human pregnancy associated plasma protein A and identification of the proform of eosinophil major basic protein as its physiological inhibitor J Biol Chem 275 40 Amerika Birlesik Devletleri ss 31128 31133 Complex of pregnancy associated plasma protein A and the proform of eosinophil major basic protein Disulfide structure and carbohydrate attachment J Biol Chem 278 4 Amerika Birlesik Devletleri Ocak 2003 ss 2106 2117 Oxvig Haziran 1993 Circulating human pregnancy associated plasma protein A is disulfide bridged to the proform of eosinophil major basic protein J Biol Chem 268 17 Amerika Birlesik Devletleri ss 12243 6 Konuyla ilgili yayinlarVanhaesebroeck B Alessi DR 2000 The PI3K PDK1 connection more than just a road to PKB Biochem J 346 3 ss 561 76 doi 10 1042 0264 6021 3460561 PMC 1220886 2 PMID 10698680 Yoshimatsu K Ohya Y Shikata Y Toshio S Yoshikazu H Isao T Tamio K Kyousuke K Satoshi T 1992 Purification and cDNA cloning of a novel factor produced by a human T cell hybridoma sequence homology with animal lectins Mol Immunol 29 4 ss 537 546 doi 10 1016 0161 5890 92 90012 M PMID 1565101 Barker RL Loegering DA Arakawa KC Pease LR Gleich GJ 1990 Cloning and sequence analysis of the human gene encoding eosinophil major basic protein Gene 86 2 ss 285 289 doi 10 1016 0378 1119 90 90292 Y PMID 2323577 Gabay JE Scott RW Campanelli D Griffith J Wilde C Marra MN Seeger M Nathan CF 1989 Antibiotic proteins of human polymorphonuclear leukocytes Proc Natl Acad Sci U S A 86 14 ss 5610 5614 Bibcode 1989PNAS 86 5610G doi 10 1073 pnas 86 14 5610 PMC 297672 2 PMID 2501794 Wasmoen TL McKean DJ Benirschke K Coulam CB Gleich GJ 1990 Evidence of eosinophil granule major basic protein in human placenta J Exp Med 170 6 ss 2051 2063 doi 10 1084 jem 170 6 2051 PMC 2189540 2 PMID 2584934 Barker RL Gleich GJ Pease LR 1988 Acidic precursor revealed in human eosinophil granule major basic protein cDNA J Exp Med 168 4 ss 1493 1498 doi 10 1084 jem 168 4 1493 PMC 2189086 2 PMID 3171483 McGrogan M Simonsen C Scott R Griffith J Ellis N Kennedy J Campanelli D Nathan C Gabay J 1989 Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein J Exp Med 168 6 ss 2295 2308 doi 10 1084 jem 168 6 2295 PMC 2189145 2 PMID 3199069 Wasmoen TL Bell MP Loegering DA Gleich GJ Prendergast FG McKean DJ 1988 Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein J Biol Chem 263 25 ss 12559 63 PMID 3410852 Weller PF Ackerman SJ Smith JA 1988 Eosinophil granule cationic proteins major basic protein is distinct from the smaller subunit of eosinophil peroxidase J Leukoc Biol 43 1 ss 1 4 doi 10 1002 jlb 43 1 1 PMID 3422083 Kristensen T Oxvig C Sand O Hundahl Moeller NP Sottrup Jensen L 1994 Amino acid sequence of human pregnancy associated plasma protein A derived from cloned cDNA Biochemistry 33 6 ss 1592 1598 doi 10 1021 bi00172a040 PMID 7508748 Oxvig C Haaning J Hojrup P Sottrup Jensen L 1994 Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum Biochem Mol Biol Int 33 2 ss 329 36 PMID 7524900 Bonno M Oxvig C Kephart GM Wagner JM Kristensen T Sottrup Jensen L Gleich GJ 1994 Localization of pregnancy associated plasma protein A and colocalization of pregnancy associated plasma protein A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta Lab Invest 71 4 ss 560 6 PMID 7526035 Li MS Sun L Satoh T Fisher LM Spry CJ 1995 Human eosinophil major basic protein a mediator of allergic inflammation is expressed by alternative splicing from two promoters Biochem J 305 3 ss 921 7 doi 10 1042 bj3050921 PMC 1136346 2 PMID 7531438 Oxvig C Haaning J Kristensen L Wagner JM Rubin I Stigbrand T Gleich GJ Sottrup Jensen L 1995 Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma J Biol Chem 270 23 ss 13645 13651 doi 10 1074 jbc 270 23 13645 PMID 7539791 Oxvig C Sand O Kristensen T Gleich GJ Sottrup Jensen L 1993 Circulating human pregnancy associated plasma protein A is disulfide bridged to the proform of eosinophil major basic protein J Biol Chem 268 17 ss 12243 6 PMID 7685339 Levi Schaffer F Lacy P Severs NJ Newman TM North J Gomperts B Kay AB Moqbel R 1995 Association of granulocyte macrophage colony stimulating factor with the crystalloid granules of human eosinophils Blood 85 9 ss 2579 86 doi 10 1182 blood V85 9 2579 bloodjournal8592579 PMID 7727786 Oxvig C Gleich GJ Sottrup Jensen L 1994 Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein PDF FEBS Lett 341 2 3 ss 213 217 doi 10 1016 0014 5793 94 80459 1 PMID 8137941 22 Eylul 2017 tarihinde kaynagindan PDF Erisim tarihi 9 Mayis 2020 Shikata Y Hayashi Y Yoshimatsu K Ohya Y Seto T Fukushima K Yoshida Y 1993 Pro major basic protein has three types of sugar chains at the pro portion Biochim Biophys Acta 1163 3 ss 243 9 doi 10 1016 0167 4838 93 90158 N PMID 8507662 Nittoh T Watanabe M Okayama H Misawa S Isobe Y Hayashi H Mue S Ohuchi K 1996 Cloning of cDNA for rat eosinophil major basic protein Biochim Biophys Acta 1264 3 ss 261 4 doi 10 1016 0167 4781 95 00183 2 PMID 8547309 Delcommenne M Tan C Gray V Rue L Woodgett J Dedhar S 1998 Phosphoinositide 3 OH kinase dependent regulation of glycogen synthase kinase 3 and protein kinase B AKT by the integrin linked kinase Proc Natl Acad Sci U S A 95 19 ss 11211 11216 Bibcode 1998PNAS 9511211D doi 10 1073 pnas 95 19 11211 PMC 21621 2 PMID 9736715 Dis baglantilarMedical Subject Headings Eosinophil Major Basic Protein PDBe KB uzerinde PDB de UniProt P13727 kemik iligi proteoglikani icin uygun butun yapisal bilgilere bir bakis